Publications by Chin-Lin Chen | EPFL Graph Search

Ascending neurons convey behavioral state to integrative sensory and action selection brain regions

Pavan P Ramdya, Florian Aymanns, Nicolas Talabot, Chin-Lin Chen

Knowing one's own behavioral state has long been theorized as critical for contextualizing dynamic sensory cues and identifying appropriate future behaviors. Ascending neurons (ANs) in the motor system that project to the brain are well positioned to provi ...

NATURE PORTFOLIO2023

Microengineered devices enable long-term imaging of the ventral nerve cord in behaving adult Drosophila

Mahmut Selman Sakar, Pavan P Ramdya, Florian Aymanns, Victor Lobato Rios, Murat Kaynak, Semih Günel, Chin-Lin Chen, Laura Joan Hermans, Jonas Friedrich Braun

The dynamics and connectivity of neural circuits continuously change on timescales ranging from milliseconds to an animal's lifetime. Therefore, to understand biological networks, minimally invasive methods are required to repeatedly record them in behavin ...

Nature Research2022

Descending neuron population dynamics during odor-evoked and spontaneous limb-dependent behaviors

Pavan P Ramdya, Florian Aymanns, Chin-Lin Chen

Deciphering how the brain regulates motor circuits to control complex behaviors is an important, long-standing challenge in neuroscience. In the fly, Drosophila melanogaster, this is coordinated by a population of similar to 1100 descending neurons (DNs). ...

eLIFE SCIENCES PUBL LTD2022

Uncovering the neural encoding of behavior in the adult Drosophila motor system

Chin-Lin Chen

One of the most important goals in neuroscience research has always been to understand how animals control their behavior. However, the long focus on the role of brain neurons in behavioral control might be missing the full story. In fact, brain-wide fluct ...

EPFL2022

Extensive and diverse patterns of cell death sculpt neural networks in insects

Pavan P Ramdya, Chin-Lin Chen

Changes to the structure and function of neural networks are thought to underlie the evolutionary adaptation of animal behaviours. Among the many developmental phenomena that generate change programmed cell death (PCD) appears to play a key role. We show t ...

2020

Serotonergic Modulation of Walking in Drosophila

Pavan P Ramdya, Chin-Lin Chen

To navigate complex environments, animals must generate highly robust, yet flexible, locomotor behaviors. For example, walking speed must be tailored to the needs of a particular environment. Not only must animals choose the correct speed and gait, they mu ...

CELL PRESS2019

Imaging neural activity in the ventral nerve cord of behaving adult Drosophila

Michaël Unser, Pavan P Ramdya, Chin-Lin Chen, Florian Aymanns, Denis Fortun, Laura Joan Hermans

To understand neural circuits that control limbs, one must measure their activity during behavior. Until now this goal has been challenging, because limb premotor and motor circuits have been largely inaccessible for large-scale recordings in intact, movin ...

Nature Research2018