Publications by Riccardo Ravasio

Bottlenecks, Modularity, and the Neural Control of Behavior

In almost all animals, the transfer of information from the brain to the motor circuitry is facilitated by a relatively small number of neurons, leading to a constraint on the amount of information that can be transmitted. Our knowledge of how animals enco ...

FRONTIERS MEDIA SA2022

Direct coupling analysis of epistasis in allosteric materials

Matthieu Wyart, Riccardo Ravasio, Carolina Brito Carvalho dos Santos, Barbara Bravi

In allosteric proteins, the binding of a ligand modifies function at a distant active site. Such allosteric pathways can be used as target for drug design, generating considerable interest in inferring them from sequence alignment data. Currently, differen ...

2020

Mechanics and co-evolution of allosteric materials and proteins

Riccardo Ravasio

The regulation of several processes inside and outside the cell depends on the action of a particular class of enzymes, called allosteric. In allosteric macromolecules, binding a ligand at one site affects the binding activity at a distal functional site, ...

EPFL2020

Maximum-energy records in glassy energy landscapes

Riccardo Ravasio, Marco Baity-Jesi

We study the evolution of the maximum energy E-max(t) reached between time 0 and time t in the dynamics of simple models with glassy energy landscapes, after an instant quench from infinite temperature to a target temperature T. Through a detailed descript ...

IOP PUBLISHING LTD2019

Allostery in Its Many Disguises: From Theory to Applications

Matthieu Wyart, Giulia Palermo, Carolina Brito Carvalho dos Santos, Jingshi Li, Riccardo Ravasio, Jing Li

Allosteric regulation plays an important role in many biological processes, such as signal transduction, transcriptional regulation, andmetabolism. Allostery is rooted in the fundamental physical properties of macromolecular systems, but its underlying mec ...

CELL PRESS2019

Mechanics of Allostery: Contrasting the Induced Fit and Population Shift Scenarios

Matthieu Wyart, Solange Marie Flatt, Carolina Brito Carvalho dos Santos, Stefano Zamuner, Riccardo Ravasio

In allosteric proteins, binding a ligand can affect function at a distant location, for example, by changing the binding affinity of a substrate at the active site. The induced fit and population shift models, which differ by the assumed number of stable c ...

CELL PRESS2019

Principles for Optimal Cooperativity in Allosteric Materials

Matthieu Wyart, Carolina Brito Carvalho dos Santos, Riccardo Ravasio

2018

Architecture and coevolution of allosteric materials

Matthieu Wyart, Riccardo Ravasio, Carolina Brito Carvalho dos Santos

We introduce a numerical scheme to evolve functional elastic materials that can accomplish a specified mechanical task. In this scheme, the number of solutions, their spatial architectures, and the correlations among them can be computed. As an example, we ...

National Academy of Sciences2017