Publications by Linlin Cao | EPFL Graph Search

Resistance mechanism to Notch inhibition and combination therapy in human T-cell acute lymphoblastic leukemia

Freddy Radtke, Romain Hamelin, Nadine Fournier, Florence Armand, Maria Pavlou, Linlin Cao

Gain-of-function mutations in NOTCH1 are among the most frequent genetic alterations in T-cell acute lymphoblastic leukemia (T-ALL), highlighting the Notch signaling pathway as a promising therapeutic target for personalized medicine. Yet, a major limitati ...

2023

Resistance mechanism to Notch inhibition and combination therapy in human T cell acute lymphoblastic leukemia

Linlin Cao

T cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematological malignancy caused by acquisition of genetic alterations during T-cell development. The 5-year overall survival of pediatric T-ALL patients has improved considerably over the past 30 ...

EPFL2023

A Rapid Translational Immune Response Program in CD8 Memory T Lymphocytes

Linlin Cao

The activation of memory T cells is a very rapid and concerted cellular response that requires coordination between cellular processes in different compartments and on different time scales. In this study, we use ribosome profiling and deep RNA sequencing ...

American Association of Immunologists ; Oxford University Press2022

NRF2 Activation Confers Resistance to eIF4A Inhibitors in Cancer Therapy

Linlin Cao

Inhibition of the eIF4A RNA helicase with silvestrol and related compounds is emerging as a powerful anti-cancer strategy. We find that a synthetic silvestrol analogue (CR-1-31 B) has nanomolar activity across many cancer cell lines. It is especially activ ...

2021

Pharmacological disruption of the Notch transcription factor complex

Freddy Radtke, Ute Koch, Nadine Fournier, Jelena Zaric, Rajwinder Lehal, Linlin Cao, Michele Vigolo

Notch pathway signaling is implicated in several human cancers. Aberrant activation and mutations of Notch signaling components are linked to tumor initiation, maintenance, and resistance to cancer therapy. Several strategies, such as monoclonal antibodies ...

National Academy of Sciences2020

Measurements of isospin asymmetry and difference of direct CP asymmetries in inclusive B -> X-s gamma decays

Olivier Schneider, Sun Hee Kim, Yiming Li, Mingkui Wang, Tara Nanut, Chao Wang, Kyung Taek Cho, Tagir Aushev, Chang-Hyun Park, Arnaud Michel Gelb

We report measurements of isospin asymmetry Delta(0-) and difference of direct CP asymmetries Delta A(CP) between charged and neutral B -> X-s gamma decays. This analysis is based on the data sample containing 772 x 10(6)B (B) over bar pairs that was colle ...

American Physical Society2019

Search for the B -> Y(4260)K, Y(4260) -> J/psi pi(+)pi(-) decays

Olivier Schneider, Mithilesh Nayak, Yiming Li, Sun Hee Kim, Mingkui Wang, Chao Wang, Kyung Taek Cho, Tagir Aushev, Yong Chan Choi, Linlin Cao

We report the results of a search for the B -> Y(4260)K, Y(4260) -> J/psi pi(+)pi thorn p-decays. This study is based on a data sample corresponding to an integrated luminosity of 711 fb(-1), collected at the Upsilon(4S) resonance with the Belle detector a ...

American Physical Society2019

Search for a Light CP-odd Higgs Boson and Low-Mass Dark Matter at the Belle Experiment

Olivier Schneider, Yiming Li, Roberto Gargiani, Chao Wang, Mithilesh Nayak, Gaétan Charles Antoine Giriat, Tagir Aushev, Sun Hee Kim, Tara Nanut, Ke Huang

We report on the first Belle search for a light CP-odd Higgs boson, A(0), that decays into low mass dark matter, chi, in final states with a single photon and missing energy. We search for events produced via the dipion transition (sic)(2S) -> (sic)(1S)pi( ...

2019

Search for the rare decay of B+ -> l(+)nu e gamma with improved hadronic tagging

Olivier Schneider, Roberto Gargiani, Yiming Li, Mingkui Wang, Mithilesh Nayak, Chao Wang, Gaétan Charles Antoine Giriat, Sun Hee Kim, Tagir Aushev, Seyed Sina Mirrazavi Salehian

We present the result of the search for the rare B meson decay of B+ -> l(+)nu e gamma with l = e, mu. For the search the full data set recorded by the Belle experiment of 711 fb(-1) integrated luminosity near the Upsilon(4S) resonance is used. Signal cand ...

American Physical Society2018

Observation of e(+) e(-) -> gamma chi(c1) and search for e(+) e(-) -> gamma chi(c0), gamma chi(c2), and gamma eta(c) at root s near 10.6 GeV at Belle

Olivier Schneider, Yiming Li, Roberto Gargiani, Mingkui Wang, Gaétan Charles Antoine Giriat, Chao Wang, Sun Hee Kim, Tagir Aushev, Timothy Chi Hin Liew, Chang-Hyun Park

Using data samples of 89.5 fb(-1), 711.0 fb(-1), and 121.4 fb(-1) collected with the Belle detector at the KEKB asymmetric-energy e(+)e(-) collider at center-of-mass energies 10.52, 10.58, and 10.867 GeV, respectively, we study the exclusive reactions e(+) ...

American Physical Society2018