Publications by Meltem Weger | EPFL Graph Search

The glucocorticoid receptor in the nucleus accumbens plays a crucial role in social rank attainment in rodents

Maria del Carmen Sandi Perez, Jocelin Grosse, Olivia Zanoletti, Fiona Hollis, Ioannis Zalachoras, Meltem Weger, Thomas Didier Larrieu, Alexandre Claude Gustave Bacq

Social hierarchy in social species is usually established through competitive encounters with conspecifics. It determines the access to limited resources and, thus, leads to reduced fights among individuals within a group. Despite the known importance of s ...

2020

MondoA regulates gene expression in cholesterol biosynthesis-associated pathways required for zebrafish epiboly

Cédric Gobet, Frédéric Bruno Martin Gachon, Benjamin Dieter Weger, Meltem Weger

The glucose-sensing Mondo pathway regulates expression of metabolic genes in mammals. Here, we characterized its function in the zebrafish and revealed an unexpected role of this pathway in vertebrate embryonic development. We showed that knockdown of mond ...

2020

Mitochondrial gene signature in the prefrontal cortex for differential susceptibility to chronic stress

Rolf Gruetter, Maria del Carmen Sandi Perez, Bart Deplancke, Jocelin Grosse, Julie Marie Russeil, Daniel Alpern, Antoine Timothée Cherix, Meltem Weger, Sriparna Ghosal

Mitochondrial dysfunction was highlighted as a crucial vulnerability factor for the development of depression. However, systemic studies assessing stress-induced changes in mitochondria-associated genes in brain regions relevant to depression symptomatolog ...

2020

Increased brain glucocorticoid actions following social defeat in rats facilitates the long-term establishment of social subordination

Maria del Carmen Sandi Perez, Jocelin Grosse, Olivia Zanoletti, Meltem Weger

Social rank is frequently established through aggressive encounters between new conspecifics. Despite increasing evidence suggesting that social rank is critical for the well-being of both humans and animals, knowledge about the factors influencing social ...

2018

High anxiety trait: A vulnerable phenotype for stress-induced depression

Maria del Carmen Sandi Perez, Meltem Weger

A great deal of research aims to identify risk factors related to individual vulnerability to develop stress-induced psychopathologies. Here, we summarize evidence that point at anxiety trait as a significant contributor to inter-individual differences in ...

2018

Stem cells and the circadian clock

Benjamin Dieter Weger, Meltem Weger

The circadian timing system is a complex biological network of interacting circadian clocks that regulates 24 h rhythms of behavioral and physiological processes. One intriguing observation is that stem cell homeostasis is subject to circadian clock regula ...

Academic Press Inc Elsevier Science2017

Extensive Regulation of Diurnal Transcription and Metabolism by Glucocorticoids

Cédric Gobet, Frédéric Bruno Martin Gachon, Benjamin Dieter Weger, Meltem Weger

Altered daily patterns of hormone action are suspected to contribute to metabolic disease. It is poorly understood how the adrenal glucocorticoid hormones contribute to the coordination of daily global patterns of transcription and metabolism. Here, we exa ...

Public Library Science2016

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Meltem Weger

The glucocorticoid receptor in the nucleus accumbens plays a crucial role in social rank attainment in rodents

MondoA regulates gene expression in cholesterol biosynthesis-associated pathways required for zebrafish epiboly

Mitochondrial gene signature in the prefrontal cortex for differential susceptibility to chronic stress

Increased brain glucocorticoid actions following social defeat in rats facilitates the long-term establishment of social subordination

Glucocorticoid deficiency causes transcriptional and post-transcriptional reprogramming of glutamine metabolism

High anxiety trait: A vulnerable phenotype for stress-induced depression

Stem cells and the circadian clock

Extensive Regulation of Diurnal Transcription and Metabolism by Glucocorticoids

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Chat with Graph Search

The glucocorticoid receptor in the nucleus accumbens plays a crucial role in social rank attainment in rodents

Mitochondrial gene signature in the prefrontal cortex for differential susceptibility to chronic stress

High anxiety trait: A vulnerable phenotype for stress-induced depression

Increased brain glucocorticoid actions following social defeat in rats facilitates the long-term establishment of social subordination

Stem cells and the circadian clock

Extensive Regulation of Diurnal Transcription and Metabolism by Glucocorticoids

MondoA regulates gene expression in cholesterol biosynthesis-associated pathways required for zebrafish epiboly

Glucocorticoid deficiency causes transcriptional and post-transcriptional reprogramming of glutamine metabolism