Publications by Yahya Mohammadzadeh

Engineering a synthetic signaling network in dendritic cells to improve anti-tumoral immunity

Effective induction of anti-tumor immunity requires dendritic cells (DCs) to internalize, process and present tumor antigens to T cells. However, the hostile tumor microenvironment (TME) impedes this process by suppressing DC maturation and antigen present ...

EPFL2024

Game changers in science and technology- now and beyond

Yahya Mohammadzadeh

The recent devastating pandemic has drastically reminded humanity of the importance of constant scientific and technological progress. A strong interdisciplinary dialogue between academic and industrial scientists of various specialties, entrepreneurs, man ...

ELSEVIER SCIENCE INC2023

Cytokine-armed dendritic cell progenitors for antigen-agnostic cancer immunotherapy

Michele De Palma, Nahal Mansouri, Ali Ghasemi, Bruno Torchia, Yahya Mohammadzadeh, Alan Nicolas Thierry Guichard

Dendritic cells (DCs) are antigen-presenting myeloid cells that regulate T cell activation, trafficking and function. Monocyte-derived DCs pulsed with tumor antigens have been tested extensively for therapeutic vaccination in cancer, with mixed clinical re ...

Nature Portfolio2023

Boosting dendritic cell nanovaccines

Michele De Palma, Yahya Mohammadzadeh

A preclinical study reports a platform for the generation of dendritic cell-derived nanovesicles with enhanced immunostimulatory function, which demonstrate promising antitumoural activity in mouse models and might overcome some of the shortcomings of earl ...

Nature Portfolio2022