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Gamma-secretase, an integral membrane protein complex, catalyzes the intramembrane cleavage of the beta-amyloid precursor protein (APP) during the neuronal production of the amyloid beta-peptide. As such, the protease has emerged as a key target for develo ...
The fragility of thin Clark-type glass microelectrodes used in aquatic eddy covariance measurements of benthic oxygen fluxes is a challenge when using this powerful technique. This study presents a new fast-responding dual oxygen-temperature sensor for edd ...
Wiley-Blackwell2016
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Gamma-secretase is an unconventional aspartyl protease that processes many type 1 membrane proteins within the lipid bilayer. Because its cleavage of amyloid-beta precursor protein generates the amyloid-beta protein (Abeta) of Alzheimer's disease, partiall ...