Publications by Alexandra Teslenko

Single-molecule analysis reveals the mechanism of chromatin ubiquitylation by variant PRC1 complexes

Chromatin regulation relies on “writer” enzymes that add posttranslational modifications to histone proteins. Variant polycomb repressive complex 1 (PRC1) exists as several subtypes, which are “writers” of ubiquitylation on histone H2A K118 and K119, cruci ...

American Association for the Advancement of Science (AAAS)2025

Mechanism of Chromatin Ubiquitination by PRC1 on the Single-Molecule Level

Alexandra Teslenko

Multicellular eukaryotic organisms contain identical genetic information within each cell, stored within the nucleus as chromatin fibers. The regulation of gene expression allows cell-type-specific temporal and spatial gene activation or repression despite ...

EPFL2024

De novo design of protein interactions with learned surface fingerprints

Didier Trono, Henning Paul-Julius Stahlberg, Beat Fierz, Priscilla Turelli, Bruno Emanuel Ferreira De Sousa Correia, Elisa Oricchio, Sandrine Madeleine Suzanne Georgeon, Dongchun Ni, Andreas Scheck, Michael Bronstein

Physical interactions between proteins are essential for most biological processes governing life. However, the molecular determinants of such interactions have been challenging to understand, even as genomic, proteomic and structural data increase. This k ...

2023

Alexandra Teslenko

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Single-molecule analysis reveals the mechanism of chromatin ubiquitylation by variant PRC1 complexes

Mechanism of Chromatin Ubiquitination by PRC1 on the Single-Molecule Level

De novo design of protein interactions with learned surface fingerprints

Short talk Single-molecule enzymology of chromatin ubiquitination

Development of a single-molecule approach to observe ubiquitination dynamics in defined chromatin states

Development of a single-molecule approach to observe ubiquitination dynamics in defined chromatin states

De novo design of protein interactions with learned surface fingerprints

Single-molecule analysis reveals the mechanism of chromatin ubiquitylation by variant PRC1 complexes

Short talk Single-molecule enzymology of chromatin ubiquitination

Development of a single-molecule approach to observe ubiquitination dynamics in defined chromatin states

Development of a single-molecule approach to observe ubiquitination dynamics in defined chromatin states

Mechanism of Chromatin Ubiquitination by PRC1 on the Single-Molecule Level