Person
Andrei Zviagin
Related publications (7)
Ion Spectroscopy Reveals Structural Difference for Proteins Microhydrated by Retention and Condensation of Water
Protein ubiquitin in its +7 charge state microhydrated by 5 and 10 water molecules has been interrogated in the gas phase by cold ion UV/IR spectroscopy. The complexes were formed either by condensing water onto the unfolded bare proteins in a temperature- ...
Washington2024Salt Bridge Structure of Microhydrated Arginine Kinetically Trapped in the Gas Phase by Evaporative Cooling
Aminoacids and peptides generally exhibit zwitterionic forms withsalt bridge (SB) structures in solution but charge-solvated (CS) motifsin the gas phase. Here, we report a study of non-covalent complexesof the protonated amino acid arginine, ArgH(+)(H2O)( ...
AMER CHEMICAL SOC2023Revealing the Structure of Tryptophan in Microhydrated Complexes by Cold Ion Spectroscopy
Natalia Nagornova, Andrei Zviagin, Ruslan Yamaletdinov, Manuel Dömer
The geometry of biomolecules isolated in the gas phaseusuallydiffers substantially from their native structures in aqueous solution,which are the only ones truly relevant to life science. To connectthe high resolution of cold ion spectroscopy that can be a ...
AMER CHEMICAL SOC2023Bridging Native and Intrinsic Structures of Microhydrated Biomolecules by Cold Ion Spectroscopy
Solving native structures of such large molecules, like biomolecules, is often challenging, particularly due to the potentially infinite number of non-covalent interactions with water. In this thesis, we report the use of cold ion gas-phase action spectros ...
EPFL2023Identification of Isomeric Biomolecules by Infrared Spectroscopy of Solvent-Tagged Ions
The difference in functionality of many isomeric biomolecules requires their analytical identification for life science studies. We present a universal approach for quantitative identification of different small- to medium-sized isomeric biomolecules that ...
AMER CHEMICAL SOC2022Gentle nano-electrospray ion source for reliable and efficient generation of microsolvated ions
Vladimir Kopysov, Andrei Zviagin
We present herein the design of a nano-electrospray ion source capable of reliable generation of large quantities of microsolvated ions. The source is based on a triple molecular skimmer scheme and can be quickly tuned to generate bare ions or their ionic ...
AIP Publishing2022Microhydration of Biomolecules: Revealing the Native Structures by Cold Ion IR Spectroscopy
Andrei Zviagin, Viktoriia Aladinskaia
The native-like structures of protonated glycine and peptide Gly3H+ were elucidated using cold ion IR spectroscopy of these biomolecules hydrated by a controlled number of water molecules. The complexes were generated directly from an aqueous solution usin ...
2021