Person
David Crettaz
Related publications (6)
In vitro-transfusional model for red-blood-cell study: the advantage of lowering hematocrit
Gerardo Turcatti, David Crettaz, Michel Prudent, Manon Sandra Bardyn
Background - Thequalityof red blood cells (RBCs) stored in red cell concentrates (RCCs) is influenced by processing, storage and donor characteristics, and can have a clinical impact on transfused patients. To evaluate RBC properties and their potential im ...
Simtipro Srl2023Image- and Fluorescence-Based Test Shows Oxidant-Dependent Damages in Red Blood Cells and Enables Screening of Potential Protective Molecules
Gerardo Turcatti, Benjamin Rappaz, David Crettaz, Michel Prudent, Manon Sandra Bardyn
An increase of oxygen saturation within blood bags and metabolic dysregulation occur during storage of red blood cells (RBCs). It leads to the gradual exhaustion of RBC antioxidant protective system and, consequently, to a deleterious state of oxidative s ...
2021Red blood cells ageing markers: a multi-parametric analysis
Gerardo Turcatti, Niels Erik Lion, Benjamin Rappaz, David Crettaz, Michel Prudent, Manon Sandra Bardyn
Background. Red blood cells collected in citrate-phosphate-dextrose can be stored for up to 42 days at 4 degrees C in saline-adenine-glucose-mannitol additive solution. During this controlled, but nevertheless artificial, ex vivo ageing, red blood cells ac ...
Simti Servizi Srl2017Stored red blood cells: A changing universe waiting for its map(s)
Niels Erik Lion, David Crettaz, Olivier Rubin
The availability of stored red blood cells (RBCs) for transfusion remains an important aspect of the treatment of polytrauma, acute anemia or major bleedings. RBCs are prepared by blood banks from whole blood donations and stored in the cold in additive so ...
2010Microparticles in stored red blood cells: an approach using flow cytometry and proteomic tools
Niels Erik Lion, David Crettaz, Olivier Rubin
Background and Objectives Microparticles (MPs) are small phospholipid vesicles of less than 1 mu m, shed in blood flow by various cell types. These MPs are involved in several biological processes and diseases. MPs have also been detected in blood products ...
Wiley-Blackwell2008Oxidation of proteins: basic principles and perspectives for blood proteomics
Niels Erik Lion, David Crettaz, Joël Stéphane Rossier
Protein oxidation mechanisms result in a wide array of modifications, from backbone cleavage or protein crosslinking to more subtle modifications such as side chain oxidations. Protein oxidation occurs as part of normal regulatory processes, as a defence m ...
2008