Konstantin Popadin

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Mitochondrial Pseudogenes Suggest Repeated Inter-Species Hybridization among Direct Human Ancestors

Konstantin Popadin

The hypothesis that the evolution of humans involves hybridization between diverged species has been actively debated in recent years. We present the following novel evidence in support of this hypothesis: the analysis of nuclear pseudogenes of mtDNA ("NUM ...

MDPI2022

A mitochondria-specific mutational signature of aging: increased rate of A > G substitutions on the heavy strand

Jacques Fellay, Konstantin Popadin, Dmitrii Iliushchenko, Stepan Denisov

The mutational spectrum of the mitochondrial DNA (mtDNA) does not resemble any of the known mutational signatures of the nuclear genome and variation in mtDNA mutational spectra between different organisms is still incomprehensible. Since mitochondria are ...

OXFORD UNIV PRESS2022

A billion-year trend of amino acid substitutions in the mitochondrial genome

Jacques Fellay, Konstantin Popadin, Valeriia Timonina, Dmitrii Iliushchenko

SPRINGERNATURE2022

Risk of mitochondrial deletions is affected by the global secondary structure of the mitochondrial genome

Jacques Fellay, Konstantin Popadin

SPRINGERNATURE2022

Mitochondrial mutational spectrum in human cancers is sensitive to cellular hypoxia

Jacques Fellay, Konstantin Popadin

SPRINGERNATURE2022

Increased CHIP prevalence amongst people living with HIV

Jacques Fellay, Konstantin Popadin

SPRINGERNATURE2022

Increased prevalence of clonal hematopoiesis of indeterminate potential amongst people living with HIV

Jacques Fellay, Christian Axel Wandall Thorball, Konstantin Popadin

People living with human immunodeficiency virus (PLWH) have significantly increased risk for cardiovascular disease in part due to inflammation and immune dysregulation. Clonal hematopoiesis of indeterminate potential (CHIP), the age-related acquisition an ...

Nature Portfolio2022

The genomic landscape of human cellular circadian variation points to a novel role for the signalosome

Frédéric Bruno Martin Gachon, Konstantin Popadin, Daniel Alain Dominique Marie Mauvoisin

The importance of natural gene expression variation for human behavior is undisputed, but its impact on circadian physiology remains mostly unexplored. Using umbilical cord fibroblasts, we have determined by genome-wide association how common genetic varia ...

Elife Sciences Publications Ltd2017

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