Publications by Omaya Pierre Dudin

DNA methylation enables recurrent endogenization of giant viruses in an animal relative

5-Methylcytosine (5mC) is a widespread silencing mechanism that controls genomic parasites. In eukaryotes, 5mC has gained complex roles in gene regulation beyond parasite control, yet 5mC has also been lost in many lineages. The causes for 5mC retention an ...

2024

Life-cycle-coupled evolution of mitosis in close relatives of animals

Omaya Pierre Dudin, Marine Olivetta

Eukaryotes have evolved towards one of two extremes along a spectrum of strategies for remodelling the nuclear envelope during cell division: disassembling the nuclear envelope in an open mitosis or constructing an intranuclear spindle in a closed mitosis1 ...

2024

A multicellular developmental program in a close animal relative

Omaya Pierre Dudin, Nicolas René Chiaruttini, Marine Olivetta

All animals develop from a single-celled zygote into a complex multicellular organism through a series of precisely orchestrated processes1,2. Despite the remarkable conservation of early embryogenesis across animals, the evolutionary origins of how and wh ...

2024

Cellularization across eukaryotes: Conserved mechanisms and novel strategies

Omaya Pierre Dudin

Many eukaryotes form multinucleated cells during their devel-opment. Some cells persist as such during their lifetime, others choose to cleave each nucleus individually using a specialized cytokinetic process known as cellularization. What is cellula-rizat ...

CURRENT BIOLOGY LTD2023

The nuclear-to-cytoplasmic ratio drives cellularization in the close animal relative Sphaeroforma arctica

Omaya Pierre Dudin, Marine Olivetta

The ratio of nuclear content to cytoplasmic volume (N/C ratio) is a key regulator driving the maternal-to -zy-gotic transition in most animal embryos. Altering this ratio often impacts zygotic genome activation and de-regulates the timing and outcome of em ...

CELL PRESS2023

Lifestyle-coupled evolution of mitosis in close animal relatives

Omaya Pierre Dudin, Marine Olivetta

AMER SOC CELL BIOLOGY2023

Regulation of sedimentation rate shapes the evolution of multicellularity in a close unicellular relative of animals

Omaya Pierre Dudin

Significant increases in sedimentation rate accompany the evolution of multicellularity. These increases should lead to rapid changes in ecological distribution, thereby affecting the costs and benefits of multicellularity and its likelihood to evolve. How ...

PUBLIC LIBRARY SCIENCE2022

Integrin-Mediated Adhesion in the Unicellular Holozoan Capsaspora owczarzaki

Omaya Pierre Dudin

In animals, cell-matrix adhesions are essential for cell migration, tissue organization, and differentiation, which have central roles in embryonic development [1-6]. Integrins are the major cell surface adhesion receptors mediating cell-matrix adhesion in ...

CELL PRESS2020

A formin-nucleated actin aster concentrates cell wall hydrolases for cell fusion in fission yeast

Thierry Laroche, Arne Seitz, Omaya Pierre Dudin, Raphaël Groux

Cell-cell fusion is essential for fertilization. For fusion of walled cells, the cell wall must be degraded at a precise location but maintained in surrounding regions to protect against lysis. In fission yeast cells, the formin Fus1, which nucleates linea ...

Rockefeller University Press2015