Publications by Ying Liu | EPFL Graph Search

The CRL5-SPSB3 ubiquitin ligase targets nuclear cGAS for degradation

Andrea Ablasser, Baptiste Claude André Guey, Jonathan Jean-Pierre Ricci, Chong Liu, Pauline Ambre Melenec, Pengbiao Xu, Lingyun Li, Ying Liu

Cyclic GMP-AMP synthase (cGAS) senses aberrant DNA during infection, cancer and inflammatory disease, and initiates potent innate immune responses through the synthesis of 2 ' 3 '-cyclic GMP-AMP (cGAMP)1-7. The indiscriminate activity of cGAS towards DNA d ...

Nature Portfolio2024

PSGL-1 is an evolutionarily conserved antiviral restriction factor

Ying Liu, Chao Jiang

The arms race between viruses and their hosts shaped the evolutionary history and the genome composition of both parties. Restriction factors are the first-line antiviral effectors encoded by the host genomes and are often conserved through evolution to pr ...

AMER SOC MICROBIOLOGY2023

Clathrin-associated AP-1 control stermination of STING signalling

Andrea Ablasser, Jonathan Jean-Pierre Ricci, Chong Liu, Pengbiao Xu, Ying Liu, Sophie Marie Elisabeth Rivara

Stimulator of interferon genes (STING) functions downstream of cyclic GMP-AMP synthase in DNA sensing or as a direct receptor for bacterial cyclic dinucleotides and small molecules to activate immunity during infection, cancer and immunotherapy(1-10). Prec ...

NATURE PORTFOLIO2022

Structural and optical properties of the Cu2ZnSnSe4 thin films grown by nano-ink coating and selenization

Jürgen Brugger, Ying Liu

Quaternary semiconductor Cu2ZnSnSe4 (CZTSe) is a very promising alternative to semiconductors based on indium (In) and gallium (Ga) as solar absorber material due to its direct band gap, inherent high absorption coefficient (> 10(4) cm(-1)) and abundance o ...

Springer Verlag2013

Endoplasmic Reticulum Stress Is Important for the Manifestations of alpha-Synucleinopathy In Vivo

Bernard Schneider, Philippe Guillaume Coune, Ying Liu

Accumulation of misfolded alpha-synuclein (alpha S) is mechanistically linked to neurodegeneration in Parkinson's disease (PD) and other alpha-synucleinopathies. However, how alpha S causes neurodegeneration is unresolved. Because cellular accumulation of ...

Society for Neuroscience2012

Dopaminergic Neuronal Loss, Reduced Neurite Complexity and Autophagic Abnormalities in Transgenic Mice Expressing G2019S Mutant LRRK2

Liliane Glauser, Klodjan Stafa, Darren Moore, Ying Liu, David Ramonet Jimenez

Mutations in the leucine-rich repeat kinase 2 (LRRK2) gene cause late-onset, autosomal dominant familial Parkinson's disease (PD) and also contribute to idiopathic PD. LRRK2 mutations represent the most common cause of PD with clinical and neurochemical fe ...

Public Library of Science2011

The MicroArray Quality Control (MAQC)-II study of common practices for the development and validation of microarray-based predictive models

Darlene Goldstein, Chenxu Zhao, Mauro Delorenzi, Li Zhang, Vlad Popovici, Jun Luo, Wen Luo, Wei Wang, Ying Liu, Jonathan Koh Boon Han

Gene expression data from microarrays are being applied to predict preclinical and clinical endpoints, but the reliability of these predictions has not been established. In the MAQC-II project, 36 independent teams analyzed six microarray data sets to gene ...

Nature Publishing Group2010