Publications by Wouter Richard Karthaus

Tackling the next decade of cancer research

Elsevier BV2025

BRCA2 reversion mutation–independent resistance to PARP inhibition through impaired DNA prereplication complex function

Recent approvals of polymeric adenosine diphosphate ribose (poly(ADP-ribose) polymerase inhibitors (PARPi) for BRCA-mutant metastatic castration resistant prostate cancer necessitate an understanding of the factors that shape sensitivity and resistance. Re ...

Proceedings of the National Academy of Sciences2025

CDC7 inhibition impairs neuroendocrine transformation in lung and prostate tumors through MYC degradation

Wouter Richard Karthaus

Neuroendocrine (NE) transformation is a mechanism of resistance to targeted therapy in lung and prostate adenocarcinomas leading to poor prognosis. Up to date, even if patients at high risk of transformation can be identified by the occurrence of Tumor Pro ...

Springer Science and Business Media LLC2024

Single-cell analysis of treatment-resistant prostate cancer: Implications of cell state changes for cell surface antigen–targeted therapies

Wouter Richard Karthaus

Targeting cell surface molecules using radioligand and antibody-based therapies has yielded considerable success across cancers. However, it remains unclear how the expression of putative lineage markers, particularly cell surface molecules, varies in the ...

National Academy of Sciences2024

Next-Generation Modeling of Cancer Using Organoids

Wouter Richard Karthaus, Jillian Rose Love

In the last decade, organoid technology has become a cornerstone in cancer research. Organoids are long-term primary cell cultures, usually of epithelial origin, grown in a three-dimensional (3D) protein matrix and a fully defined medium. Organoids can be ...

Cold Spring Harbor Lab Press, Publications Dept2024

Exportin 1 inhibition prevents neuroendocrine transformation through SOX2 down-regulation in lung and prostate cancers

Wouter Richard Karthaus

In lung and prostate adenocarcinomas, neuroendocrine (NE) transformation to an aggressive derivative resembling small cell lung cancer (SCLC) is associated with poor prognosis. We previously described dependency of SCLC on the nuclear transporter exportin ...

2023

Lineage plasticity in prostate cancer depends on FGFR and JAK/STAT inflammatory signaling

Yixing Chen, Wouter Richard Karthaus, Jian Zhao, Hung-Hsu Chan

ELSEVIER SCI LTD2022

Lineage plasticity in prostate cancer depends on JAK/STAT inflammatory signaling

Wouter Richard Karthaus, Jillian Rose Love, Yu Chen

Drug resistance in cancer is often linked to changes in tumor cell state or lineage, but the molecular mechanisms driving this plasticity remain unclear. Using murine organoid and genetically engineered mouse models, we investigated the causes of lineage p ...

American Association for the Advancement of Science (AAAS)2022