The Sharing Economy, or the economy of sharing, is an economic phenomenon that has rapidly spread in recent years, transforming the ways in which resources and services are accessed and consumed. This phenomenon has had a significant impact on consumption ...
Springer Science and Business Media Deutschland GmbH2024
Tepotinib is approved for the treatment of patients with non-small-cell lung cancer harboring MET exon 14 skipping alterations. While edema is the most prevalent adverse event (AE) and a known class effect of MET inhibitors including tepotinib, there is st ...
The development of immune checkpoint inhibitors (ICIs) has revolutionized cancer therapy but only a fraction of patients benefits from this therapy. Model-informed drug development can be used to assess prognostic and predictive clinical factors or biomark ...
With wind power providing an increasing amount of electricity worldwide, the quantification of its spatio-temporal variations and the related uncertainty is crucial for energy planners and policy-makers. Here, we propose a methodological framework which (1 ...
