Publication
Sulfide-binding hemoglobins: effects of mutations on active-site flexibility
Related concepts (32)
Heme
Heme (American English), or haem (Commonwealth English, both pronounced /hi:m/ ), is a precursor to hemoglobin, which is necessary to bind oxygen in the bloodstream. Heme is biosynthesized in both the bone marrow and the liver. In biochemical terms, heme is a coordination complex "consisting of an iron ion coordinated to a porphyrin acting as a tetradentate ligand, and to one or two axial ligands." The definition is loose, and many depictions omit the axial ligands.
Whale watching
Whale watching is the practice of observing whales and dolphins (cetaceans) in their natural habitat. Whale watching is mostly a recreational activity (cf. birdwatching), but it can also serve scientific and/or educational purposes. A study prepared for International Fund for Animal Welfare in 2009 estimated that 13 million people went whale watching globally in 2008. Whale watching generates $2.1 billion per annum in tourism revenue worldwide, employing around 13,000 workers.
Whale feces
Whale feces, the excrement of whales, has a significant role in the ecology of the oceans, and whales have been referred to as "marine ecosystem engineers". Nitrogen released by cetacean species and iron chelate is a significant benefit to the marine food chain in addition to sequestering carbon for long periods. Whale feces can give information on a number of aspects of the health, natural history and ecology of an animal or group as it contains DNA, hormones, toxins, and other chemicals.
Chemical bond
A chemical bond is a lasting attraction between atoms or ions that enables the formation of molecules, crystals, and other structures. The bond may result from the electrostatic force between oppositely charged ions as in ionic bonds, or through the sharing of electrons as in covalent bonds. The strength of chemical bonds varies considerably; there are "strong bonds" or "primary bonds" such as covalent, ionic and metallic bonds, and "weak bonds" or "secondary bonds" such as dipole–dipole interactions, the London dispersion force, and hydrogen bonding.
Hydrogen fluoride
Hydrogen fluoride (fluorane) is an inorganic compound with chemical formula . It is a very poisonous, colorless gas or liquid that dissolves in water to yield an aqueous solution termed hydrofluoric acid. It is the principal industrial source of fluorine, often in the form of hydrofluoric acid, and is an important feedstock in the preparation of many important compounds including pharmaceuticals and polymers, e.g. polytetrafluoroethylene (PTFE). HF is also widely used in the petrochemical industry as a component of superacids.
Cetacean stranding
Cetacean stranding, commonly known as beaching, is a phenomenon in which whales and dolphins strand themselves on land, usually on a beach. Beached whales often die due to dehydration, collapsing under their own weight, or drowning when high tide covers the blowhole. Cetacean stranding has occurred since before recorded history. Several explanations for why cetaceans strand themselves have been proposed, including changes in water temperatures, peculiarities of whales' echolocation in certain surroundings, and geomagnetic disturbances, but none have so far been universally accepted as a definitive reason for the behavior.
Ligand field theory
Ligand field theory (LFT) describes the bonding, orbital arrangement, and other characteristics of coordination complexes. It represents an application of molecular orbital theory to transition metal complexes. A transition metal ion has nine valence atomic orbitals - consisting of five nd, one (n+1)s, and three (n+1)p orbitals. These orbitals are of appropriate energy to form bonding interaction with ligands. The LFT analysis is highly dependent on the geometry of the complex, but most explanations begin by describing octahedral complexes, where six ligands coordinate to the metal.
Heme A
Heme A (or haem A) is a heme, a coordination complex consisting of a macrocyclic ligand called a porphyrin, chelating an iron atom. Heme A is a biomolecule and is produced naturally by many organisms. Heme A, often appears a dichroic green/red when in solution, is a structural relative of heme B, a component of hemoglobin, the red pigment in blood. Heme A differs from heme B in that a methyl side chain at ring position 8 is oxidized to a formyl group and a hydroxyethylfarnesyl group, an isoprenoid chain, has been attached to the vinyl side chain at ring position 2 of the iron tetrapyrrole heme.
Orca
The orca (Orcinus orca), also called killer whale, is a toothed whale belonging to the oceanic dolphin family, of which it is the largest member. It is the only extant species in the genus Orcinus and is recognizable by its black-and-white patterned body. A cosmopolitan species, orcas can be found in all of the world's oceans in a variety of marine environments, from Arctic and Antarctic regions to tropical seas. Orcas are apex predators and have a diverse diet. Individual populations often specialize in particular types of prey.
Active site
In biology and biochemistry, the active site is the region of an enzyme where substrate molecules bind and undergo a chemical reaction. The active site consists of amino acid residues that form temporary bonds with the substrate, the binding site, and residues that catalyse a reaction of that substrate, the catalytic site. Although the active site occupies only ~10–20% of the volume of an enzyme, it is the most important part as it directly catalyzes the chemical reaction.