Structure-activity relationships for ruthenium(II)-arene drugs
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The aim of the study is to evaluate the differences of protein binding of NAMI-A, a new ruthenium drug endowed with selective antimetastatic properties, and of cisplatin and to ascertain the possibility to use two drugs based on heavy metals in combination ...
Organometallic ruthenium(II)-arene complexes are currently attracting increasing interest as anticancer compds. with the potential to overcome drawbacks of traditional drugs like cisplatin with respect to resistance, selectivity, and toxicity. Rational des ...
The trinuclear Ru complexes [RuCl2(PAd2Bu)]3 (1) and [RuCl2(PtBu2Cy)]3 (2) were obtained by reaction of [(p-cymene)RuCl2]2 with 2 equiv of the resp. sterically demanding phosphine. Crystallog. analyses of 1 and 2 show that the three metal fragments are con ...
Several washing agents ( EDTA, CDTA, NTA, 8 HQS, Ti-EDTA- citrate, Ca2+, and H+) were tested for their ability to extract adsorbed metal from biological surfaces to distinguish between internalized and total cellular metal (Pb, Ni, Cd, Zn, and Cu) for a gr ...
A new simulation technique (three-dimensional dislocation dynamics) enabling the capture of a hardening effect in metals due to irradiation is reported. When bombarded with high-energy particles, metals accrue internal damage. In irradiated Pd, for example ...
The organometallic approach to diversity-oriented org. synthesis was subjected to a further test, this time in the phenol series. The model compds. selected were 2,3,6-trifluorophenol, the three isomers of (trifluoromethoxy)phenol and the three isomers of ...
The discovery of new metal-based antitumor drugs, whether cisplatin derivs. or those based on other metals, has been largely based on cell viability assays (IC50 values) and compds. that bind to DNA. This approach has been applied for more than 30 years du ...