Superparamagnetic iron oxide nanoparticle coupled tissue soldering

The invention relates to superparamagnetic iron oxide nanoparticles for use in sutureless thermal mediated tissue fusion. The nanoparticles are dispersed in a biocompatible solder material and heated by application of an alternating electromagnetic field. The invention furthermore relates to a pharmaceutical preparation comprising superparamagnetic iron oxide nanoparticles, preferably with a diameter of below 20 nm, and such nanoparticles coated with an organic compound and/or imbedded in a biocompatible material, for example a soldering agent. The invention likewise relates to the use of superparamagnetic iron oxide nanoparticles for the manufacture of a medicament for use in tissue fusion with an alternating electromagnetic field, and to a method of tissue fusion wherein superparamagnetic iron oxide nanoparticles dispersed in a biocompatible interface material are heated by application of an alternating electromagnetic field.

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Nanoparticle

A nanoparticle or ultrafine particle is usually defined as a particle of matter that is between 1 and 100 nanometres (nm) in diameter. The term is sometimes used for larger particles, up to 500 nm, or fibers and tubes that are less than 100 nm in only two directions. At the lowest range, metal particles smaller than 1 nm are usually called atom clusters instead.

Silver nanoparticle

Silver nanoparticles are nanoparticles of silver of between 1 nm and 100 nm in size. While frequently described as being 'silver' some are composed of a large percentage of silver oxide due to their large ratio of surface to bulk silver atoms. Numerous shapes of nanoparticles can be constructed depending on the application at hand. Commonly used silver nanoparticles are spherical, but diamond, octagonal, and thin sheets are also common. Their extremely large surface area permits the coordination of a vast number of ligands.

Iron oxide nanoparticle

Iron oxide nanoparticles are iron oxide particles with diameters between about 1 and 100 nanometers. The two main forms are composed of magnetite () and its oxidized form maghemite (γ-). They have attracted extensive interest due to their superparamagnetic properties and their potential applications in many fields (although cobalt and nickel are also highly magnetic materials, they are toxic and easily oxidized) including molecular imaging.

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