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Superparamagnetic iron oxide nanoparticle coupled tissue soldering

Heinrich Hofmann, Alke Fink, Benedikt Steitz
2007
Patent
Abstract

The invention relates to superparamagnetic iron oxide nanoparticles for use in sutureless thermal mediated tissue fusion. The nanoparticles are dispersed in a biocompatible solder material and heated by application of an alternating electromagnetic field. The invention furthermore relates to a pharmaceutical preparation comprising superparamagnetic iron oxide nanoparticles, preferably with a diameter of below 20 nm, and such nanoparticles coated with an organic compound and/or imbedded in a biocompatible material, for example a soldering agent. The invention likewise relates to the use of superparamagnetic iron oxide nanoparticles for the manufacture of a medicament for use in tissue fusion with an alternating electromagnetic field, and to a method of tissue fusion wherein superparamagnetic iron oxide nanoparticles dispersed in a biocompatible interface material are heated by application of an alternating electromagnetic field.

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