Publications related to The Genetics Company, Inc. - A newly founded Swiss Biotech Company

Genetic dissection of the role of BMP signaling for the development of the auditory brainstem nuclei and the large calyx of Held synapse

Synapses are key elements for communication within the complex network of neurons that make up our brain. Interestingly, synaptic connections can differ greatly in form and function, depending on the specific circuit into which they are embedded. In this P ...

EPFL2016

Bioengineering approaches to guide stem cell-based organogenesis

Matthias Lütolf, Adrian Ranga, Nikolche Gjorevski

During organogenesis, various molecular and physical signals are orchestrated in space and time to sculpt multiple cell types into functional tissues and organs. The complex and dynamic nature of the process has hindered studies aimed at delineating morpho ...

Company of Biologists2014

TGR5 reduces macrophage migration through mTOR-induced C/EBP beta differential translation

Kristina Schoonjans, Alessia Perino, Matthias Alexander Sokrates Stein, Mitsunori Nomura, Thijs Pols

The bile acid-responsive G protein-coupled receptor TGR5 is involved in several metabolic processes, and recent studies suggest that TGR5 activation may promote pathways that are protective against diet-induced diabetes. Here, we investigated the role of m ...

American Society for Clinical Investigation2014

Bioluminescent and micro-computed tomography imaging of bone repair induced by fibrin-binding growth factors

Jeffrey Alan Hubbell, Mikaël Martino

In this work we have evaluated the capacity of bone morphogenetic protein-2 (BMP-2) and fibrin-binding platelet-derived growth factor-BB (PDGF-BB) to support cell growth and induce bone regeneration using two different imaging technologies to improve the u ...

Elsevier Sci Ltd2014

Randomized codon mutagenesis reveals that the HIV Rev arginine-rich motif is robust to substitutions and that double substitution of two critical residues alters specificity

Maroun Bou Sleiman

The binding of the arginine-rich motif (ARM) of HIV Rev protein to its high-affinity site in stem IIB in the Rev response element (RRE) initiates assembly of a ribonucleoprotein complex that mediates the export of essential, incompletely spliced viral tran ...

Wiley-Blackwell2013

Proangiogenic Hydrogels Within Macroporous Scaffolds Enhance Islet Engraftment in an Extrahepatic Site

Jeffrey Alan Hubbell, Mikaël Martino

The transplantation of allogeneic islets in recent clinical trials has shown substantial promise as a therapy for type 1 diabetes; however, long-term insulin independence remains inadequate. This has been largely attributed to the current intravascular, he ...

Mary Ann Liebert, Inc2013

Partial promoter substitutions generating transcriptional sentinels of diverse signaling pathways in embryonic stem cells and mice

Anne Grapin-Botton

Extracellular signals in development, physiology, homeostasis and disease often act by regulating transcription. Herein we describe a general method and specific resources for determining where and when such signaling occurs in live animals and for systema ...

Company Of Biologists Ltd2012

Definition of in Vitro Microenvironments to Characterize and Control Pancreatic Progenitor Expansion and Differentiation

Chiara Greggio

The pancreas plays a central role in metabolism. The exocrine pancreas, composed of ductal and acinar cells, secretes and delivers digestive enzymes into the duodenum where they contribute to food digestion. The endocrine pancreas, constituted by the islet ...

EPFL2011

Beta amyloid and hyperphosphorylated tau deposits in the pancreas in type 2 diabetes

László Forró, Aleksandra Radenovic, Andras Kis

Strong epidemiologic evidence suggests an association between Alzheimer disease (AD) and type 2 diabetes. To determine if amyloid beta (A

\beta

) and hyperphosphorylated tau occurs in type 2 diabetes, pancreas tissues from 21 autopsy cases (10 type 2 diabe ...

Elsevier2010

A self-regulatory system of interlinked signaling feedback loops controls mouse limb patterning

Felix Naef, Mirko Bischofberger

Embryogenesis depends on self-regulatory interactions between spatially separated signaling centers, but few of these are well understood. Limb development is regulated by epithelial-mesenchymal (e-m) feedback loops between sonic hedgehog (SHH) and fibrobl ...

2009

The Genetics Company, Inc. - A newly founded Swiss Biotech Company

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Genetic dissection of the role of BMP signaling for the development of the auditory brainstem nuclei and the large calyx of Held synapse

Bioengineering approaches to guide stem cell-based organogenesis

TGR5 reduces macrophage migration through mTOR-induced C/EBP beta differential translation

Bioluminescent and micro-computed tomography imaging of bone repair induced by fibrin-binding growth factors

Randomized codon mutagenesis reveals that the HIV Rev arginine-rich motif is robust to substitutions and that double substitution of two critical residues alters specificity

Proangiogenic Hydrogels Within Macroporous Scaffolds Enhance Islet Engraftment in an Extrahepatic Site

Partial promoter substitutions generating transcriptional sentinels of diverse signaling pathways in embryonic stem cells and mice

Definition of in Vitro Microenvironments to Characterize and Control Pancreatic Progenitor Expansion and Differentiation

Beta amyloid and hyperphosphorylated tau deposits in the pancreas in type 2 diabetes

A self-regulatory system of interlinked signaling feedback loops controls mouse limb patterning

Genetic dissection of the role of BMP signaling for the development of the auditory brainstem nuclei and the large calyx of Held synapse

TGR5 reduces macrophage migration through mTOR-induced C/EBP beta differential translation

Proangiogenic Hydrogels Within Macroporous Scaffolds Enhance Islet Engraftment in an Extrahepatic Site

Bioluminescent and micro-computed tomography imaging of bone repair induced by fibrin-binding growth factors

Partial promoter substitutions generating transcriptional sentinels of diverse signaling pathways in embryonic stem cells and mice

A self-regulatory system of interlinked signaling feedback loops controls mouse limb patterning

Randomized codon mutagenesis reveals that the HIV Rev arginine-rich motif is robust to substitutions and that double substitution of two critical residues alters specificity

Definition of in Vitro Microenvironments to Characterize and Control Pancreatic Progenitor Expansion and Differentiation

Bioengineering approaches to guide stem cell-based organogenesis

Beta amyloid and hyperphosphorylated tau deposits in the pancreas in type 2 diabetes