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Nineteen additional unpredicted transcripts from human chromosome 21
Related publications (37)
The THO complex counteracts TERRA R-loop-mediated telomere fragility in telomerase(+) cells and telomeric recombination in ALT(+) cells
Joachim Lingner, Rita Valador Fernandes
Telomeres are the nucleoprotein structures at the ends of linear chromosomes. Telomeres are transcribed into long non-coding Telomeric Repeat-Containing RNA (TERRA), whose functions rely on its ability to associate with telomeric chromatin. The conserved T ...
OXFORD UNIV PRESS2023Combining phylogeny and coevolution improves the inference of interaction partners among paralogous proteins
Anne-Florence Raphaëlle Bitbol
Author summaryWhen two protein families interact, their sequences feature statistical dependencies. First, interacting proteins tend to share a common evolutionary history. Second, maintaining structure and interactions through the course of evolution yiel ...
PUBLIC LIBRARY SCIENCE2023A generic diffusion-based approach for 3D human pose prediction in the wild
Alexandre Massoud Alahi, Saeed Saadatnejad, Taylor Ferdinand Mordan
Predicting 3D human poses in real-world scenarios, also known as human pose forecasting, is inevitably subject to noisy inputs arising from inaccurate 3D pose estimations and occlusions. To address these challenges, we propose a diffusion-based approach th ...
IEEE2023Expression and differential regulation of human TERRA at several chromosome ends
Joachim Lingner, Marianna Feretzaki, Patricia Renck Nunes
The telomeric long noncoding RNA TERRA has been implicated in regulating telomere maintenance by telomerase and homologous recombination, and in influencing telomeric protein composition during the cell cycle and the telomeric DNA damage response. TERRA tr ...
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT2019RDHK Family, Regulators dedicated to Organohalide Respiration - Sequence Diversity and Functional Prediction
Christof Holliger, Julien Maillard, Mathilde Stéphanie Willemin
Organohalide respiration (OHR) is an anaerobic metabolism by which bacteria conserve energy from the use of organohalide molecules as terminal electron acceptors. Because most organohalides of anthropogenic origin are persistent pollutants, the study of ba ...
2019RDHK Family, Regulators dedicated to Organohalide Respiration - Sequence Diversity and Functional Prediction
Christof Holliger, Julien Maillard, Mathilde Stéphanie Willemin
Organohalide respiration (OHR) is an anaerobic metabolism by which bacteria conserve energy from the use of organohalide molecules as terminal electron acceptors. Because most organohalides of anthropogenic origin are persistent pollutants, the study of ba ...
2019ORGANOHALIDE RESPIRATION: STUDY OF THE MEMBRANE PROTEIN COMPLEX RESPONSIBLE FOR THE REDUCTION OF HALOGENATED COMPOUNDS
Christof Holliger, Julien Maillard, Adrian Schmid, Lorenzo Cimmino
Organohalide respiration (OHR) is a bacterial anaerobic respiratory process in which halogenated compounds are used as terminal electron acceptors. Desulfitobacterium and Dehalobacter, paradigmatic organohalide-respiring bacteria (OHRB), harbour the pceABC ...
2019Fatigue life modeling and prediction methods for composite materials and structures—Past, present, and future prospects
This chapter aims to provide an overview of the fatigue life modeling and prediction methods for composite materials and structures, recalling methods used in the past, discovering the present status, and attempting to foresee future trends. ...
Elsevier2019Functional characterization of 3D protein structures informed by human genetic diversity
Amalio Telenti, Istvan Bartha, Julia di Iulio
Sequence variation data of the human proteome can be used to analyze 3D protein structures to derive functional insights. We used genetic variant data from nearly 140,000 individuals to analyze 3D positional conservation in 4,715 proteins and 3,951 homolog ...
PNAS2019Evaluating the similarity of biochemical reactions and its uses for mapping novel and orphan reactions to protein sequences
Recent advances in synthetic biochemistry have resulted in a wealth of de novo hypothetical enzymatic reactions that are not matched to protein-encoding genes, deeming them “orphan”. Nearly half of known metabolic enzymes are also orphan, leaving important ...
2018