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Salt restriction induces pseudohypoaldosteronism type 1 in mice expressing low levels of the beta-subunit of the amiloride-sensitive epithelial sodium channel

Related publications (35)

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Novel theory and potential applications of central diastolic pressure decay time constant

Nikolaos Stergiopoulos, Georgios Rovas, Sokratis Anagnostopoulos, Vasiliki Bikia, Patrick Segers

Central aortic diastolic pressure decay time constant ( ) is according to the two-element Windkessel model equal to the product of total peripheral resistance (R) times total arterial compliance (C ). As such, it is related to arterial stiffness, which has ...

2024

Modulation of Pulsatile Left Ventricular Afterload by Renal Denervation in Heart Failure With Preserved Ejection Fraction

Nikolaos Stergiopoulos, Stamatia Zoi Pagoulatou

Background:Arterial stiffening contributes to hemodynamic derangements in heart failure with preserved ejection fraction (HFpEF). We sought to investigate the impact of renal denervation on pulsatile left ventricular loading in patients with HFpEF and hype ...

Philadelphia2023

Implanted System for Orthostatic Hypotension in Multiple-System Atrophy

Grégoire Courtine, Jocelyne Bloch, Jordan Squair, Léonie Asboth, Robin Jonathan Demesmaeker, Nicolas Hankov, Sergio Daniel Hernandez, Grégory Didier Dumont, Suje Amir, Maxime Berney

Orthostatic hypotension is a cardinal feature of multiple-system atrophy. The upright posture provokes syncopal episodes that prevent patients from standing and walking for more than brief periods. We implanted a system to restore regulation of blood press ...

MASSACHUSETTS MEDICAL SOC2022

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Left ventricular end-systolic elastance (Ees) is a major determinant of cardiac systolic function and ventricular-arterial interaction. Previous methods for the Ees estimation require the use of the echocardiographic ejection fraction (EF). However, given ...

2021

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Introduction Modern imaging techniques such as blood oxygen level-dependent (BOLD) functional magnetic resonance imaging (fMRI) allow the non-invasive and indirect measurement of brain activity. Whether changes in signal intensity can be detected in small ...

2020

Towards Continuous and Ambulatory Blood Pressure Monitoring: Methods for Efficient Data Acquisition for Pulse Transit Time Estimation

Lara Orlandic

We developed a prototype for measuring physiological data for pulse transit time (PTT) estimation that will be used for ambulatory blood pressure (BP) monitoring. The device is comprised of an embedded system with multimodal sensors that streams high-throu ...

2020

We discuss causal mediation analyses for survival data and propose a new approach based on the additive hazards model. The emphasis is on a dynamic point of view, that is, understanding how the direct and indirect effects develop over time. Hence, importan ...

2020

How Do We Analyze Effects of Low Diastolic Blood Pressure?

Mats Julius Stensrud

Lee and colleagues “sought to determine whether the development of diastolic hypotension during treatment was associated with adverse outcomes”.1 They used a conventional proportional hazards model employing diastolic blood pressure as a time-varying expos ...

2019

Introduction Baroreflex sensitivity (BRS) is essential to ensure rapid adjustment to variations in blood pressure (BP). Spontaneous baroreflex function can be assessed using continuous recordings of blood pressure. The goal of this study was to compare fou ...

FRONTIERS MEDIA SA2019

Background and aims Reducing the diastolic blood pressure (DBP) below a certain threshold may lead to inadequate organ perfusion. This raises some concerns, because pharmacotherapy reduces both systolic and diastolic pressure. We aimed to investigate wheth ...

2017