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Alveolar and lactogenic differentiation

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Mechanisms underlying cell-fate determination in the mammary gland development

Duje Buric

Notch signaling pathway is an important developmental pathway and has been implicated in both mammary gland development and tumorigenesis. Several studies investigating Notch signaling in mouse mammary gland implied that Notch signaling is an important fac ...

EPFL2015

Lead Optimisation of a Novel Small Molecule Notch Inhibitor

Viktoria Reinmüller

Notch signalling represents a form of cell-to-cell communication that plays a pivotal role for cellular organisation during embryonic and postnatal development, as well as in the homeostasis of adult organs and tissues. Malfunction of this signalling pathw ...

EPFL2015

Targeting cytokine networks in KRAS-driven tumorigenesis

KRAS is one of the most commonly mutated oncogenes in human tumors, and is typically associated with aggressive disease. Despite intensive study and years of effort, KRAS has remained refractory to targeted inhibition. Given the challenge of inhibiting KRA ...

Expert Reviews2014

DNA sensing unchained

Andrea Ablasser

In two recent reports in Science, James Chen and colleagues provide compelling evidence that detection of cytosolic DNA triggers the production of a novel second messenger, cyclic GMP-AMP (cGAMP), which in turn activates a signaling pathway that induces ty ...

2013

Integrated modeling of flow and residence times at the catchment scale with multiple interacting pathways

There is still a need for catchment hydrological and transport models that properly integrate the effects of preferential flows while accounting for differences in velocities and celerities. A modeling methodology is presented here which uses particle trac ...

Amer Geophysical Union2013

ER and PR signaling nodes during mammary gland development

Cathrin Brisken, Tamara Tanos, Lucia Jimenez Rojo

The ovarian hormones estrogen and progesterone orchestrate postnatal mammary gland development and are implicated in breast cancer. Most of our understanding of the molecular mechanisms of estrogen receptor (ER) and progesterone receptor (PR) signaling ste ...

BioMed Central2012

Paracrine signaling by progesterone

Cathrin Brisken, Renuga Devi Rajaram

Steroid hormones coordinate and control the development and function of many organs and are implicated in many pathological processes. Progesterone signaling, in particular, is essential for several important female reproductive functions. Physiological ef ...

Elsevier2012

Exploration of trade-offs between steady-state and dynamic properties in signaling cycles

Dominique Bonvin, Vassily Hatzimanikatis, Benoît Chachuat, Andrijana Radivojevic

In the intracellular signaling networks that regulate important cell processes, the base pattern comprises the cycle of reversible phosphorylation of a protein, catalyzed by kinases and opposing phosphatases. Mathematical modeling and analysis have been us ...

Iop Publishing Ltd2012

Exploring the therapeutic space around NAD+

Johan Auwerx, Richardus Houtkooper

NAD(+) is a central metabolite in the cell. Changes in NAD(+) abundance and the activity of NAD(+)-dependent enzymes, such as the sirtuins, are at the core of metabolic/mitochondrial diseases, such as obesity and diabetes, and of cancer and neurodegenerati ...

Rockefeller University Press2012

Identification of Signaling Mechanisms Determining the Development of Large Excitatory Synapses in the Lower Auditory System

Le Xiao

In the brainstem auditory circuit of mammals and birds, excitatory synapses with extraordinarily large size have evolved, which ensure fast membrane potential signaling mediated by large, multiquantal excitatory postsynaptic currents (EPSCs). The so-called ...

EPFL2011