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Opening and refolding of simian virus 40 and in vitro packaging of foreign DNA

Related publications (37)

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Direct and Retrograde Transduction of Nigral Neurons with AAV6, 8, and 9 and Intraneuronal Persistence of Viral Particles

Patrick Aebischer, Bernard Schneider

Recombinant adeno-associated viral (AAV) vectors of serotypes 6, 8, and 9 were characterized as tools for gene delivery to dopaminergic neurons in the substantia nigra for future gene therapeutic applications in Parkinson's disease. While vectors of all th ...

Mary Ann Liebert2013

RNAi Screening Reveals Proteasome- and Cullin3-Dependent Stages in Vaccinia Virus Infection

Henning Paul-Julius Stahlberg

A two-step, automated, high-throughput RNAi silencing screen was used to identify host cell factors required during vaccinia virus infection. Validation and analysis of clustered hits revealed previously unknown processes during virus entry, including a me ...

Elsevier BV2012

UV radiation induces genome-mediated, site-specific cleavage in viral protein

Tamar Kohn, Yury Tsybin, Laure Menin, Krista Rule Wigginton, Michele Cascella, Hisham Ben Hamidane, Anne Thérèse Sigstam

Much research has been dedicated to understanding the molecular basis of UV damage to biomolecules, yet many questions remain regarding the specific pathways involved. Here we describe a genome-mediated mechanism that causes sitespecific virus protein clea ...

2012

Three dimensional morphology of rabies virus studied by cryo-electron tomography

Paul Guichard

The rabies virus (RABV) continues to be a worldwide health problem. RABV contains a single-stranded RNA genome that associates with the nucleoprotein N. The resulting ribonucleoprotein complex is surrounded by matrix protein M, lipid bilayer and glycoprote ...

2011

A new study is presented on the electro-deoxidation of porous TiO2 precursors in molten calcium chlo- ride electrolytes. It is shown that by reducing precursor open porosity from standard values of ≥25% to ∼11–12%, such that there is insufficient free volu ...

Elsevier2011

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The tropism of retroviruses relies on their ability to exploit cellular factors for their replication as well as to avoid host-encoded inhibitory activities such as TRIM5α. N-tropic murine leukemia virus is sensitive to human TRIM5α (huTRIM5α) restriction, ...

American Society for Biochemistry and Molecular Biology2010

The serum-amyloid-P-component-like pentraxin from Limulus polyphemus, a recently discovered pentraxin species and important effector protein of the hemolymph immune system, displays two distinct doubly stacked cyclic molecular aggregations, heptameric and ...

Elsevier BV2009

The antiviral adaptor proteins Cardif and Trif are processed and inactivated by caspases

Etienne Meylan

The outcome of a viral infection depends on the interplay between the host's capacity to trigger potent antiviral responses and viral mechanisms that counteract them. Although Toll-like receptor (TLR)-3, which recognizes virally derived double-stranded (ds ...

Nature Publishing Group2008

Interfering residues narrow the spectrum of MLV restriction by human TRIM5alpha

Didier Trono, Priscilla Turelli, Séverine Reynard, Pierre Maillard

TRIM5alpha is a restriction factor that limits infection of human cells by so-called N- but not B- or NB-tropic strains of murine leukemia virus (MLV). Here, we performed a mutation-based functional analysis of TRIM5alpha-mediated MLV restriction. Our resu ...

Public Library of Science2007

Viral transport of DNA damage that mimics a stalled replication fork

Peter Martin Beard, Andrzej Stasiak

Adeno-associated virus type 2 (AAV2) infection incites cells to arrest with 4N DNA content or die if the p53 pathway is defective. This arrest depends on AAV2 DNA, which is single stranded with inverted terminal repeats that serve as primers during viral D ...

2005