Publication
How adeno-associated virus Rep78 protein arrests cells completely in S phase
Related publications (51)
A mathematical description of regulation of the G1-S transition of the mammalian cell cycle
A math. model of regulation of the G1-S transition of the mammalian cell cycle has been formulated to organize available exptl. mol.-level information in a systematic quant. framework and to evaluate the ability of this manifestation of current knowledge t ...
1999ATP-site directed inhibitors of cyclin-dependent kinases
Cyclin-dependent kinases trigger and coordinate transitions between different phases the cell division cycle (CDK1, 2, 3, 4, 6, 7). They also play a role in apoptosis (CDK2), in neuronal cells (CDK5) and in the control of transcription (CDK 7, 8, 9). Inten ...
Bentham Science Publishers1999Complete inhibition of Cdk/cyclin by one molecule of p21(Cip1)
Cell-cycle phase transitions are controlled by cyclin-dependent kinases (Cdks). Key to the regulation of these kinase activities are Cdk inhibitors, proteins that are induced in response to various antiproliferative signals but that can also oscillate duri ...
Cold Spring Harbor Laboratory Press1998A model of Cdc25 phosphatase catalytic domain and Cdk-interaction surface based on the presence of a rhodanese homology domain
Mammalian Cdc25 phosphatase is responsible for the dephosphorylation of Cdc2 and other cyclin-dependent kinases at Thr14 and Tyr15, thus activating the kinase and allowing cell cycle progression. The catalytic domain of this dual-specificity phosphatase ha ...
1998Recombinant cyclin E expression activates proliferation and obviates surface attachment of Chinese hamster ovary (CHO) cells in protein-free medium
Exogenous growth factors normally required in cell culture activate cell proliferation via the mol. controls of cell-cycle progression. Highly differing influences of mitogenic stimulation of Chinese hamster ovary (CHO) cells by insulin and basic fibroblas ...
1995A Mathematical Model for the G1/S Transition of the Mammalian Cell Cycle
Genetic intervention in cell-cycle regulation is a promising strategy to obtain mammalian cell culture proliferation in the absence of exogenous growth factors. In order to gain insights into this approach, known interactions among the four proteins cyclin ...
1995roughex is a dose-dependent regulator of the second meiotic division during Drosophila spermatogenesis
During spermatogenesis, germ cells execute two meiotic divisions, then withdraw from the cell cycle and initiate postmeiotic differentiation. We show that the gene roughex (rux) is a dose-dependent regulator of meiosis II during Drosophila spermatogenesis. ...
1994