The mRNA-binding protein which controls ferritin and transferrin receptor expression is conserved during evolution
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The cell-surface receptor for transferrin mediates cellular uptake of iron from serum. Transferrin receptor protein and mRNA levels are increased in cells treated with iron chelating agents, and are decreased by treatment with iron salts or hemin. Here we ...
Iron is essential to cell proliferation. Its uptake by cells requires specific binding of the major serum iron-transport protein, transferrin, to cell surface transferrin receptors, followed by endocytosis of the receptor-ligand complexes and release of ir ...
Iron regulates human transferrin receptor (hTR) expression by modulating the stability of cytoplasmic hTR mRNA. This regulation requires a distinct secondary structure in the mRNA 3' untranslated region. We identified a specific cytoplasmic factor that bin ...
