Inversion-induced disruption of the Hoxd cluster leads to the partition of regulatory landscapes
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Intimal hyperplasia (IH) is a vascular remodeling process which often leads to failure of arterial bypass or hemodialysis access. Experimental and clinical work have provided insight in IH development; however, further studies under precise controlled cond ...
Neocortical function and malfunction depends critically on a spectrum of inhibitory interneurons. To gain novel insight in normal brain function and mechanisms leading to diseases, such as epilepsy or schizophrenia, the knowledge about the specific functio ...
We report evidence for a mechanism for the maintenance of long-range conserved synteny across vertebrate genomes. We found the largest mammal-teleost conserved chromosomal segments to be spanned by highly conserved noncoding elements (HCNEs), their develop ...
The publication of a draft of the human genome and of large collections of transcribed sequences has made it possible to study the complex relationship between the transcriptome and the genome. In the work presented here, we have focused on mapping mRNA 3' ...
The polymerase chain reaction (PCR), with cDNA as template, has been widely used to identify members of protein families from many species. A major limitation of using cDNA in PCR is that detection of a family member is dependent on temporal and spatial pa ...
Translation is a central cellular process in every organism and understanding translation from the systems (genome-wide) perspective is very important for medical and biochem. engineering applications. Moreover, recent advances in cell-wide monitoring tool ...
Indirect genotype to phenotype mappings in the form of developmental systems may allow better scalability to larger phenotypes in evolvable hardware. This report reviews developmental systems used in evolvable hardware and it proposes a new classifications ...
