Publication
Spontaneous and evoked synaptic rewiring in the neonatal neocortex
Related publications (79)
Principles of Network Plasticity in Neocortical Microcircuits
Synaptic plasticity underlies our ability to learn and adapt to the constantly changing environment. The phenomenon of synapses changing their efficacy in an activity-dependent manner is often studied in small groups of neurons in vitro or indirectly throu ...
EPFL2023Different responses of mice and rats hippocampus CA1 pyramidal neurons to in vitro and in vivo-like inputs
Ying Shi, Armando Romani, Michele Migliore, Maurizio Ferdinando Pezzoli, Rosanna Migliore
The fundamental role of any neuron within a network is to transform complex spatiotemporal synaptic input patterns into individual output spikes. These spikes, in turn, act as inputs for other neurons in the network. Neurons must execute this function acro ...
2023A conditional glutamatergic synaptic vesicle marker for Drosophila
Evelyne Ruchti, Brian Donal McCabe
Glutamate is a principal neurotransmitter used extensively by the nervous systems of all vertebrate and invertebrate animals. It is primarily an excitatory neurotransmitter that has been implicated in nervous system development, as well as a myriad of brai ...
OXFORD UNIV PRESS INC2022Cell-type-specific nicotinic input disinhibits mouse barrel cortex during active sensing
Carl Petersen, Sylvain Crochet, Célia Roxane Gasselin, Benoît Hohl
Fast synaptic transmission relies upon the activation of ionotropic receptors by neurotransmitter release to evoke postsynaptic potentials. Glutamate and GABA play dominant roles in driving highly dynamic activity in synaptically connected neuronal circuit ...
CELL PRESS2021Miniature neurotransmission is required to maintain Drosophila synaptic structures during ageing
Olivier Burri, Evelyne Ruchti, Brian Donal McCabe, Soumya Banerjee, Wei Jiao
The decline of neuronal synapses is an established feature of ageing accompanied by the diminishment of neuronal function, and in the motor system at least, a reduction of behavioural capacity. Here, we have investigated Drosophila motor neuron synaptic te ...
NATURE RESEARCH2021Excitatory/inhibitory neuronal metabolic balance in mouse hippocampus upon infusion of [U-C-13(6)]glucose
Rolf Gruetter, Hongxia Lei, Bernard Lanz, Carole Poitry-Yamate, Antoine Timothée Cherix, Guillaume Donati, Blanca Lizarbe Serra
Hippocampus plays a critical role in linking brain energetics and behavior typically associated to stress exposure. In this study, we aimed to simultaneously assess excitatory and inhibitory neuronal metabolism in mouse hippocampus in vivo by applying (18) ...
2020Response Adaptation in Barrel Cortical Neurons Facilitates Stimulus Detection during Rhythmic Whisker Stimulation in Anesthetized Mice
Rodents use rhythmic whisker movements at frequencies between 4 and 12 Hz to sense the environment that will be disturbed when the animal touches an object. The aim of this work is to study the response adaptation to rhythmic whisker stimulation trains at ...
Society for Neuroscience2019A null model of the mouse whole-neocortex micro-connectome
Henry Markram, Eilif Benjamin Muller, Michael Reimann, Ying Shi, Huanxiang Lu
In connectomics, the study of the network structure of connected neurons, great advances are being made on two different scales: that of macro- and meso-scale connectomics, studying the connectivity between populations of neurons, and that of micro-scale c ...
2019Human Cortical Pyramidal Neurons: From Spines to Spikes via Models
Idan Segev, Ruth Benavides Piccione, Guy Eyal, Yair Deitcher
We present detailed models of pyramidal cells from human neocortex, including models on their excitatory synapses, dendritic spines, dendritic NMDA- and somatic/axonal Na(+) spikes that provided new insights into signal processing and computational capabil ...
2018Dual action of L-Lactate on the activity of NR2B-containing NMDA receptors: from potentiation to neuroprotection
Pierre Magistretti, Igor Allaman, Pierre Marquet, Pascal Jourdain, Kaspar Rothenfusser
L-Lactate is a positive modulator of NMDAR-mediated signaling resulting in plasticity gene induction and memory consolidation. However, L-Lactate is also able to protect neurons against excito-toxic NMDAR activity, an indication of a mitigating action of L ...
NATURE PUBLISHING GROUP2018