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The blue brain project

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Task-Driven Activity Reduces the Cortical Activity Space of the Brain: Experiment and Whole-Brain Modeling

Patric Hagmann

How a stimulus or a task alters the spontaneous dynamics of the brain remains a fundamental open question in neuroscience. One of the most robust hallmarks of task/stimulus-driven brain dynamics is the decrease of variability with respect to the spontaneou ...

Public Library Science2015

Global tractography with embedded anatomical priors and microstructure information for quantitative connectomics

Alia Lemkaddem

Over the last decades new technologies have shed the light on an improved understanding of brain structure and function. Recently, an imaging modality referred to as diffusion Magnetic Resonance Imaging (dMRI) has emerged. By exploiting the natural motion ...

EPFL2015

Multiphoton microscopy in brain imaging

Graham Knott, Bohumil Maco, Ludovico Silvestri

Brain imaging is becoming an important field in the frame of the neurophotonics in correlations with other medical ones in neuroscience studying functional and morphological aspects. In this presentation an overview on multi photon imaging of the brain wil ...

Spie-Int Soc Optical Engineering2015

The research community is witnessing expansive efforts aimed at understanding one of the most wondrous manifestations of cognition in nature. The Blue Brain Project and the Human Brain Project in Europe are examples of ambitious drives aimed at building a ...

Institute of Electrical and Electronics Engineers2014

Although twenty-first century neuroscience is a major scientific enterprise, advances in basic research have not yet translated into benefits for society. In this paper, I outline seven fundamental challenges that need to be overcome. First, neuroscience h ...

2013

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Simulations have become key in many scientific disciplines to better understand natural phenomena. Neuroscientists, for example, build and simulate increasingly fine grained models (including subcellular details, e.g., neurotransmitter) of the neocortex to ...

2013

Despite cash-strapped times for research, several ambitious collaborative neuroscience projects have attracted large amounts of funding and media attention. In Europe, the Human Brain Project aims to develop a large-scale computer simulation of the brain, ...

Nature Publishing Group2013

Multisensory experiences influence subsequent memory performance and brain responses. Studies have thus far concentrated on semantically congruent pairings, leaving unresolved the influence of stimulus pairing and memory sub-types. Here, we paired images w ...

Elsevier2012

The Human Brain Project (HBP) is a candidate project in the European Union's FET Flagship Program, funded by the ICT Program in the Seventh Framework Program. The project will develop a new integrated strategy for understanding the human brain and a novel ...

Elsevier Science, Reg Sales Off, Customer Support Dept, 655 Ave Of The Americas, New York, Ny 10010 Usa2011

Predictive Engineering the Membrane Composition of Neocortical Neurons

Georges Khazen

The brain is the most mysterious and intricate biological structure known to man. It dominates the way we live, think, reason and behave. It is built of billions of neurons that communicate with each other through trillions of connections using electrical ...

EPFL2011