Does locally delivered Zoledronate influence peri-implant bone formation? – Spatio-temporal monitoring of bone remodeling in vivo

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Sub-trabecular strain evolution in human trabecular bone

To comprehend the most detrimental characteristics behind bone fractures, it is key to understand the material and tissue level strain limits and their relation to failure sites. The aim of this study was to investigate the three-dimensional strain distrib ...

NATURE RESEARCH2020

Bioengineering human bone marrow models to elucidate the triggers of the stem cell niche

Queralt Vallmajó Martín

The bone marrow (BM) microenvironment, or niche, significantly affects behaviors of its resident stem cell populations. Disruptions in the BM niche contribute to a number of severe clinical pathologies. Discovery of novel therapeutic strategies for BM-rela ...

EPFL2019

Non-setting, injectable biomaterials containing particulate hydroxyapatite can increase primary stability of bone screws in cancellous bone

Dominique Pioletti, Ulrike Kettenberger, Jorge Solana Munoz

BACKGROUND: Fracture fixation in weak bone is still a clinical challenge. Screw augmentation was shown to successfully increase their primary stability. The currently used calcium phosphate or polymeric bone cements, however, present important drawbacks su ...

2018

Effect of temporal onsets of mechanical loading on bone formation inside a tissue engineering scaffold combined with cell therapy

Dominique Pioletti, Tanja Cloé Hausherr

Several approaches to combine bone substitutes with biomolecules, cells or mechanical loading have been explored as an alternative to the limitation and risk-related bone auto- and allo-grafts. In particular, human bone progenitor cells seeded in porous po ...

2018

Fretting corrosion between bone and calcium phosphate-calcium titanate coatings

Stefano Mischler, Adriana Esguerra Arce

Biocompatibility is one of the biggest challenges for biomaterials development. This issue arises in the case of coatings. Calcium phosphate (CP) coatings are currently used to cover femoral stem implants, while calcium titanate (CT) has also been proposed ...

ELSEVIER SCIENCE SA2018

Fiber density of collagen grafts impacts rabbit urethral regeneration

Peter Frey, Jeffrey Alan Hubbell, Hans Mattias Larsson, Elif Vardar, Kalitha Pinnagoda, Ganesh Vythilingam

There is a need for efficient and “off-the-shelf” grafts in urethral reconstructive surgery. Currently available surgical techniques require harvesting of grafts from autologous sites, with increased risk of surgical complications and added patient discomf ...

Nature Research2018

Calcium phosphate formation on titanium-based surfaces: bioactivity evaluated by in vitro methods

Weitian Zhao

The prediction of implant behaviors in vivo by the use of easy-to-perform in vitro methods is of great interest in biomaterials research. In the field of bone implants, it is commonly accepted that a spontaneous formation of a hydroxyapatite (HA) layer on ...

EPFL2018

Effect of a collar on subsidence and local micromotion of cementless femoral stems: in vitro comparative study based on micro-computerised tomography

Dominique Pioletti, Alexandre Terrier, Valérie Hélène Emilie Malfroy Camine

Purpose The aim of this study is to quantitatively compare the difference in primary stability between collarless and collared versions of the same femoral stem. Specifically, we tested differences in subsidence and micromotion. Methods Collarless and coll ...

2018

In vitro and in vivo investigation of bisphosphonate-loaded hydroxyapatite particles for peri-implant bone augmentation

Dominique Pioletti, Ulrike Kettenberger

Locally applied bisphosphonates, such as Zoledronate, have been shown in several studies to inhibit peri-implant bone resorption and recently to enhance peri-implant bone formation. Studies have also demonstrated positive effects of hydroxyapatite particle ...

Wiley-Blackwell2017

Human bone progenitor cells for clinical application: what kind of immune reaction does fetal xenograft tissue trigger in immuno-competent rats?

Dominique Pioletti, Lee Ann Laurent-Applegate, Tanja Cloé Hausherr

The potential of human fetal bone cells for successful bone regeneration has been shown in vivo. In particular, it has been demonstrated that the seeding of these cells in porous poly-(L-lactic acid)/ ß-tricalcium phosphate scaffolds improved the bone form ...

Cognizant Communication Corp2017

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