Nickel Complexes of a Pincer NN2 Ligand: Multiple Carbon-Chloride Activation of CH2Cl2 and CHCl3 Leads to Selective Carbon-Carbon Bond Formation
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The goal of this thesis is to develop new carbon-carbon bond forming reactions using inexpensive and simple coupling partners like aryl halides (pseudohalides), sulfonyl derivatives, Grignard reagents, alkenes and alkynes with metal catalysis, preferably u ...
NiII complexes of the new pincer amidobis(amine) ligand are described. The Ni chloride complex catalyzes Kumada-Corriu-Tamao coupling of unactivated alkyl halides with alkyl Grignard reagents, as well as double C-C coupling of CH2Cl2 with alkyl Grignard re ...
Long-chain hydrocarbons carrying vinyl groups, chlorine atoms or oxygen functions at the terminal positions can be prepd. with excellent yields by copper mediated coupling of alkyl tosylates and Grignard reagents. E.g., Li2CuCl4 catalyzed the coupling of C ...
The relative reactivities of fluorobenzene, all di-, tri-, and tetrafluorobenzenes and pentafluorobenzene toward sec-butyllithium have been assessed in THF at -100 DegC. At this temp. no subsequent transmetalation reactions take place but those compromise ...
The pyrans I (R = Me, H; R1 = H) with BuLi/KOCMe3 or KSiMe3 gave the 2-metalated derivs. I (R1 = K), which reacted with alkyl halides to give I (R = H, Me; R1 = Me, Et, SiMe3, CH2SiMe3); thus the behavior the 4H-pyrans toward organometallic reagents is sim ...
Alk-2-enesulfonyl chlorides 1-4 were synthesized by the BCl3-promoted ene reaction of alkenes with SO2. These sulfonyl chlorides were then used as electrophilic partners in iron-catalyzed desulfinylative cross-coupling reactions with different Grignard rea ...
The title reaction is realized by using an isolated NiII complex (1). The catalysis tolerates a wide range of important functional groups that are often incompatible with Grignard reagents in cross-coupling reactions. ...
A nickel(II) pincer complex [(MeNN2)NiCl] (1) catalyzes Kumada−Corriu−Tamao cross coupling of nonactivated alkyl halides with aryl and heteroaryl Grignard reagents. The coupling of octyl bromide with phenylmagnesium chloride was used as a test reaction. Us ...
A series of relatively low-cost ionic liquids, based on the N-butyronitrile pyridinium cation C(3)CNpy, designed to improve catalyst retention, have been prepared and evaluated in Suzuki and Stille coupling reactions. Depending on the nature of the an ...
Consecutive treatment of (trifluoromethoxy)benzene with sec-butyllithium and electrophilic reagents affords previously inaccessible ortho-substituted derivs. in generally excellent yields. 2-(Trifluoromethoxy)phenyllithium acts as the key intermediate. The ...