Particle-Shadow Tracking – Combining Magnetic Particle Manipulation with In-Situ Optical Detection in a CMOS Microsystem

We present a hybrid CMOS based microsystem where magnetic actuation of microparticles is combined with integrated optical detection via Single Photon Avalanche Diodes (SPADs). The system’s configuration permits the manipulation and detection of single magnetic particles having diameters of 1, 3 and 5 µm. We are able to show a size sensitivity of the particle detection, with a clear distinction between different particle diameters.

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Edoardo Charbon, Ulrike Lehmann, Cristiano Niclass, Stefano Pietrocola
2007
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https://infoscience.epfl.ch/record/125271?ln=en

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Particle Shadow Tracking - Combining Magnetic Particle Manipulation with In-Situ Optical Detection in a CMOS Microsystem

Edoardo Charbon, Martinus Gijs, Ulrike Lehmann, Cristiano Niclass, Stefano Pietrocola

2007

Microparticle photometry in a CMOS microsystem combining magnetic actuation and in-situ optical detection

Edoardo Charbon, Emile Dupont, Martinus Gijs, Ulrike Lehmann, Cristiano Niclass, Stefano Pietrocola

We present a hybrid CMOS-based microfluidic system that combines magnetic actuation of microparticles with in situ optical detection using single photon avalanche diodes (SPADs). The decoupling of the principles used for actuation and sensing permits a high sensitivity with respect to detection and particle handling. Single magnetic microparticles are transported within a glass micro-capillary positioned over an array of actuation coils and are detected upon passage over a SPAD, where they block incident light and thus lower the photon count. Use of the photometry method allows the determination of the particle size, which, in combination with a simultaneous measurement of the particle velocity, enables us to estimate further particle properties, such as their magnetization.We present the successful manipulation, detection and evaluation of magnetic particles with diameters ranging from 1 to 30 um.

2008

Hybrid Small Animal Imaging System Combining Magnetic Resonance Imaging with Fluorescence Tomography Using Single Photon Avalanche Diode Detectors

Christof Baltes, Lucio Carrara, Edoardo Charbon, Markus Rudin

The high sensitivity of fluorescence imaging enables the detection of molecular processes in living organisms. However, diffuse light propagation in tissue prevents accurate recovery of tomographic information on fluorophore distribution for structures embedded deeper than 0.5 mm. Combining optical with magnetic resonance imaging (MRI) provides an accurate anatomical reference for fluorescence imaging data and thereby enables the correlation of molecular with high quality structural/ functional information. We describe an integrated system for small animal imaging incorporating a noncontact fluorescence molecular tomography (FMT) system into an MRI detector. By adopting a free laser beam design geometrical constraints imposed by the use of optical fibers could be avoided allowing for flexible fluorescence excitation schemes. Photon detection based on a single-photon avalanche diode array enabled simultaneous FMT/MRI measurements without interference between modalities. In vitro characterization revealed good spatial accuracy of FMT data and accurate quantification of dye concentrations. Feasibility of FMT/MRI was demonstrated in vivo by simultaneous assessment of protease activity and tumor morphology in murine colon cancer xenografts.

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