Publication
Analysis of the S. pombe signalling scaffold protein Cdc11p reveals an essential role for the N-terminal domain in SIN signalling
Related publications (33)
A role for the carbon source of the cell and protein kinase A in regulating the S. pombe septation initiation network
Viesturs Simanis, Andrea Krapp, Bastien Mangeat, Özge Uysal Özdemir
The septation initiation network (SIN) is a conserved signal transduction network, which is important for cytokinesis in Schizosaccharomyces pombe. The SIN component Etd1p is required for association of some SIN proteins with the spindle pole body (SPB) du ...
2024Primary data for "A role for the carbon source of the cell and protein kinase A in regulating the S. pombe septation initiation network"
Viesturs Simanis, Andrea Krapp, Bastien Mangeat, Özge Uysal Özdemir
The Septation Initiation Network (SIN) is a conserved signal transduction network, which is important for cytokinesis in S. pombe. The SIN component Etd1p is required for association of some SIN proteins with the spindle pole body (SPB) during anaphase and ...
EPFL Infoscience2024Primary data for EPFL thesis "Characterisation of conditional alleles of the Schizosaccharomyces pombe cytokinesis regulator byr4"
Regulation of cytokinesis is essential for the cell during its division cycle. Failure to do so can lead to aneuploidy, which can be fatal and lead to senescence or cancer. A useful model organism for studying cytokinesis in eukaryotes is Schizosaccharomyc ...
EPFL Infoscience2023Characterisation of conditional alleles of the Schizosaccharomyces pombe cytokinesis regulator byr4
Regulation of cytokinesis is essential for the cell during its division cycle. Failure to do so can lead to aneuploidy, which can be fatal and lead to senescence or cancer. A useful model organism for studying cytokinesis in eukaryotes is Schizosaccharomyc ...
EPFL2023Centromere structure and function: lessons from Drosophila
The fruit fly Drosophila melanogaster serves as a powerful model organism for advancing our understanding of biological processes, not just by studying its similarities with other organisms including ourselves but also by investigating its differences to u ...
Bethesda2023Primary data for EPFL thesis "Metabolic regulation of cytokinesis in Schizosaccharomyces pombe"
All cells need to be able to sense their environment, and adapt their metabolism, growth and cell division appropriately. In this study, I examined the response of Schizosaccharomyces pombe to a change in the carbon source and how that affects cytokinesis. ...
EPFL Infoscience2022Metabolic regulation of cytokinesis in Schizosaccharomyces pombe
All cells need to be able to sense their environment, and adapt their metabolism, growth and cell division appropriately. In this study, I examined the response of Schizosaccharomyces pombe to a change in the carbon source and how that affects cytokinesis. ...
EPFL2022Principles of checkpoint override
Why biological quality-control systems fail is often mysterious. Specifically, checkpoints such as the DNA damage checkpoint or the spindle assembly checkpoint are overriden after prolonged arrests allowing cells to continue dividing despite the continued ...
EPFL2022Centromeres are dismantled by foundational meiotic proteins Spo11 and Rec8
Meiotic processes are potentially dangerous to genome stability and could be disastrous if activated in proliferative cells. Here we show that two key meiosis-defining proteins, the topoisomerase Spo11 (which forms double-strand breaks) and the meiotic coh ...
NATURE RESEARCH2021Pulchelloid A, a sesquiterpene lactone from the Canadian prairie plant Gaillardia aristata inhibits mitosis in human cells
Pierre Gönczy, Georgios Hatzopoulos, Tatiana Favez
Background The Canadian prairie ecosystem presents a rich source of natural products from plants that are subjected to herbivory by grazing mammals. This type of ecological competition may contribute to the production of natural products of interest in cel ...
SPRINGER2021