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Magnetic resonance imaging is one of the most efficient diagnostic modalities in clinical radiology and biomedical research. To enhance image contrast, paramagnetic complexes, mainly Gd3+ chelates, are used. Today, around one third of all medical MR images ...
Complexes of lanthanide (III) ions have been used in structural studies of biomolecules and as contrast agents (CA). Clinically approved CAs have only one water molecule in their first coordination sphere. Structure and water exchange rate of these complex ...
A compound binding three Gd3+ ions, {Ph-4Gd(DTTA)(H2O)(2) (3)} (where H(5)DTTA is diethylenetriaminetetraacetic acid), has been synthesized around a hydrophobic center made up of four phenyl rings. In aqueous solution the molecules start to self-aggre ...
Springer2014
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Three PEGylated derivatives of 6-amino-2-[4,7,10-tris(carboxymethyl)-1,4,7,10-tetrazacyclododec-1-yl]hexanoic acid (DOTA-AHA) with different molecular weights were prepared and characterized. Their Gd-III chelates were studied in aqueous solution through v ...
Wiley-Blackwell2015
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Aqueous acrylamide gels can be used to provide dynamic nuclear polarization (DNP) NMR signal enhancements of around 200 at 9.4 T and 100 K. The enhancements are shown to increase with crosslinker concentration and low concentrations of the AMUPol biradical ...
A detailed description of a merged beam apparatus for the study of low energy molecular scattering is given. This review is intended to guide any scientist who plans to construct a similar experiment, and to provide some inspiration in describing the appro ...
The need for magnetic resonance imaging (MRI) contrast agents with improved relaxivity maintains the development of new Gd-III chelates as an intensive and demanding field of research. In this work, we introduce the new dimeric chelators bis{1,4,7,10-tetra ...
Two new complexes based on pyridine-2,3,5,6-tetracarboxylic acid(H(4)pdtc) as ligand, {[Co-2(pdtc)(H2O)(4)]center dot H2O}(n) (1) and {Mn-2(pdtc)(H2O)(4)}(n) (2), have been obtained by hydrothermal syntheses and characterized by IR, elemental analysis, X-r ...
Elsevier Science Bv2015
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Magnetite nanoparticles with a size of 5-6 nm with potential impact on biomedicine and information/communication technologies were synthesized by thermal decomposition of Fe(acac)(3) and subsequently coated with a silica shell exploiting a water-in-oil syn ...
The quantification of nanoparticles, particularly superparamagnetic iron oxide nanoparticles (SPIONs), both in vitro and in vivo has become highly important in recent years. Some methods, such as induced coupled plasma (ICP) spectroscopy and UV-visible che ...
