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Differential translational regulation of IRE-containing mRNAs in Drosophila melanogaster by endogenous IRP and a constitutive human IRP1 mutant

Related publications (49)

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Iron status influences non-alcoholic fatty liver disease in obesity through the gut microbiome

Xavier Fernandez-Real Girona

Background: The gut microbiome and iron status are known to play a role in the pathophysiology of nonalcoholic fatty liver disease (NAFLD), although their complex interaction remains unclear. Results: Here, we applied an integrative systems medicine approa ...

BMC2021

Organohalide respiration in Firmicutes: energy metabolism and transcription regulation

Mathilde Stéphanie Willemin

Organohalides are a class of compounds often considered as persistent pollutants and harmful to environmental and human health. Some bacteria, among which are representatives from the Firmicutes phylum, are capable of using these compounds as terminal acce ...

EPFL2021

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Complex I (NADH:ubiquinone oxidoreductase, NUO) and complex I-like enzymes have been detected in several organohalide-respiring bacteria at genomic and proteomic levels. The question of the involvement of these enzymes in organohalide respiration remains t ...

2021

Iron deficiency is an important subclinical disease affecting over one billion people worldwide. A growing body of clinical records supports the use of intravenous iron-carbohydrate complexes for patients where iron replenishment is necessary and oral iron ...

2020

Spin cascade and doming in ferric hemes: Femtosecond X-ray absorption and X-ray emission studies

Majed Chergui, Oliviero Cannelli, Christopher Alexander Arrell, Wojciech Gawelda, Giulia Fulvia Mancini, Frederico Alves Lima, Camila Bacellar Cases Da Silveira, Dominik Kinschel, Rebecca Ann Ingle, Jérémy Raymond Jean Maurice Rouxel, Samuel Menzi

The structure-function relationship is at the heart of biology, and major protein deformations are correlated to specific functions. For ferrous heme proteins, doming is associated with the respiratory function in hemoglobin and myoglobins. Cytochrome c (C ...

NATL ACAD SCIENCES2020

Integrated Bio/Nano/CMOS Interfaces for Electrochemical Molecular Sensing

Sandro Carrara

Integrated bio/nano/Complementary Metal-Oxide-Semiconductor (CMOS) interfaces for electrochemical molecular sensing are becoming more and more common in the literature, especially for developing new electronic biochips for smart and intelligent Internet-of ...

WILEY2018

Iron phosphate nanoparticles for food fortification: Biological effects in rats and human cell lines

Christian Ludwig, Mohamed Tarik

Nanotechnology offers new opportunities for providing health benefits in foods. Food fortification with iron phosphate nanoparticles (FePO4 NPs) is a promising new approach to reducing iron deficiency because FePO4 NPs combine high bioavailability with sup ...

Informa Healthcare2017

Iron regulatory proteins and their role in controlling iron metabolism

Cellular iron homeostasis is regulated by post-transcriptional feedback mechanisms, which control the expression of proteins involved in iron uptake, release and storage. Two cytoplasmic proteins with mRNA-binding properties, iron regulatory proteins 1 and ...

Royal Soc Chemistry2015

Although the contribution of carbohydrate catabolism to bacterial colonization and infection is well recognized, the transcriptional changes during these processes are still unknown. In this study, we have performed comparative global gene expression analy ...

Public Library of Science2013

Proximal tubule H-ferritin mediates iron trafficking in acute kidney injury

Lukas Kühn

Ferritin plays a central role in iron metabolism and is made of 24 subunits of 2 types: heavy chain and light chain. The ferritin heavy chain (FtH) has ferroxidase activity that is required for iron incorporation and limiting toxicity. The purpose of this ...

American Society for Clinical Investigation2013