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Synchronous versus asynchronous modeling of gene regulatory networks

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Background: Proteins are the primary regulatory agents of transcription even though mRNA expression data alone, from systems like DNA microarrays, are widely used. In addition, the regulation process in genetic systems is inherently non-linear in nature, a ...

2007

One of the most important advances in biology in recent years may be the discovery of RNAs that can regulate gene expression. As one kind of such functional noncoding RNAs, microRNAs (miRNAs) forma class of endogenous 19–23-nucleotide RNAs that can have im ...

Wiley-Blackwell2006

Reconstruction of Switching Thresholds in Piecewise-Affine Models of Genetic Regulatory Networks

Giancarlo Ferrari Trecate

Recent advances of experimental techniques in biology have led to the production of enormous amounts of data on the dynamics of genetic regulatory networks. In this technical report, we present an approach for the identification of PieceWise-Affine (PWA) m ...

2006

Recent advances of experimental techniques in biology have led to the production of enormous amounts of data on the dynamics of genetic regulatory networks. In this paper, we present an approach for the identification of PieceWise-Affine (PWA) models of ge ...

Springer-Verlag2006

Prediction of Regulatory Modules Comprising MicroRNAs and Target Genes

Giovanni De Micheli

Motivation: MicroRNAs are small endogenous RNAs that can play important regulatory roles via the RNA-interference pathway by targeting mRNAs for cleavage or translational repression. We propose a computational method to predict miRNA regulatory modules or ...

2005

Prediction of regulatory modules comprising microRNAs and target genes

Giovanni De Micheli

Motivation: MicroRNAs (miRNAs) are small endogenous RNAs that can play important regulatory roles via the RNA-interference pathway by targeting mRNAs for cleavage or translational repression. We propose a computational method to predict mi ...

Oxford University Press2005

Linux Network Traffic Control -- Implementation Overview

Linux offers a rich set of traffic control functions. This document gives an overview of the design of the respective kernel code, describes its structure, and illustrates the addition of new elements by describing a new queuing discipline. ...

1999

1998

A major impediment of cellular automata (CA) stems from the difficulty of utilizing their complex behavior to perform useful computations. Recent studies by Packard and Mitchell et al. have shown that CAs can be evolved to perform a computational task. In ...

1996