Conformational changes due to membrane binding and channel formation by staphylococcal alpha-toxin
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Mycobacterium tuberculosis is a slow-growing intracellular bacterium with the ability to induce host cell death and persist indefinitely in the human body. This pathogen uses the specialized ESX-1 secretion system to secrete virulence factors and potent im ...
ABC toxins are pore-forming virulence factors produced by pathogenic bacteria. YenTcA is the pore-forming and membrane binding A subunit of the ABC toxin YenTc, produced by the insect pathogen Yersinia entomophaga. Here we present cryo-EM structures of Yen ...
The mechanism by which interfaces in solution can be polarised depends on the nature of the charge carriers. In the case of a conductor, the charge carriers are electrons and the polarisation is homogeneous in the plane of the electrode. In the case of an ...
Lipid membranes are self-assembled structures whose composition determines the properties of membranes of cells and organelles. The molecular level understanding of lipid membranes is based on spectroscopy and MD simulations of lipid monolayer systems. As ...
Hybrid lipid/nanoparticle membranes are suitable model systems both to study the complex interactions between nanoparticles and biological membranes, and to demonstrate technological concepts in cellular sensing and drug delivery. Unfortunately, embedding ...
Lipid membranes provide diverse and essential functions in our cells relating to transport, energy harvesting and signaling. This variety of functions is controlled by the molecular architecture, such as the presence of hydrating water, specific chemical c ...
Integral and peripheral membrane proteins account for one-third of the human proteome, and they are estimated to represent the target for over 50% of modern medicinal drugs. Despite their central role in medicine, the complex, heterogeneous and dynamic nat ...
Resistance to last-resort carbapenem antibiotics is an increasing threat to human health, as it critically limits therapeutic options. Metallo-beta-lactamases (MBLs) are the largest family of carbapenemases, enzymes that inactivate these drugs. Among MBLs, ...
A theoretical consideration of the so-called "membrane-in-the-middle" optomechanical cavity revealed that it undergoes a spontaneous symmetry breaking as a function of transparency of the membrane. Such typical features of this phenomenon as a square-root ...
Two-dimensional (2D) materials with atom- or few-atoms-thick layers have emerged as building-blocks in the synthesis of the next-generation membrane-based separations. Generally, 2D material-based membranes display high permeation and high selectivity due ...