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Late endosomal cholesterol accumulation leads to impaired intra-endosomal trafficking

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Surface-structure-regulated cell-membrane penetration by monolayer-protected nanoparticles

Francesco Stellacci, Ying Hu

Nanoscale objects are typically internalized by cells into membrane-bounded endosomes and fail to access the cytosolic cell machinery. Whereas some biomacromolecules may penetrate or fuse with cell membranes without overt membrane disruption, no synthetic ...

2008

Dependence of reversibility and progression of mouse neuronopathic Gaucher disease on acid beta-glucosidase residual activity levels

Genetic and chemically induced neuronopathic mouse models of Gaucher disease were developed to facilitate understanding of the reversibility and/or progression of CNS involvement. The lethality of the skin permeability barrier defect of the complete gene k ...

2008

Diversity of raft-like domains in late endosomes

Françoise Gisou van der Goot Grunberg

BACKGROUND: Late endosomes, the last sorting station in the endocytic pathway before lysosomes, are pleiomorphic organelles composed of tubular elements as well as vesicular regions with a characteristic multivesicular appearance, which play a crucial role ...

Public Library of Science2007

Eukaryotic cells are organized into a complex system of subcompartments, each with its distinct protein and lipid composition. A continuous flux of membranes crosses these compartments, and in some cases direct connections exist between the different organ ...

2007

The Golgi complex (GC) represents the central junction for membrane trafficking. Protein and lipid cargoes continuously move through the GC in both anterograde and retrograde directions, departing to and arriving from diverse destinations within the cell. ...

2007

Dynamics of GPI-anchored proteins on the surface of living cells

Françoise Gisou van der Goot Grunberg

Rather than being distributed homogeneously on the cell surface, proteins are probably aggregated in clusters or in specific domains. Some of these domains (lipid rafts) have lipid compositions, which differ from their surrounding membrane. They have been ...

2006

Oiling the key hole

Françoise Gisou van der Goot Grunberg

Many bacteria have been found to interact with specialized domains, rich in cholesterol and sphingolipids, of the host plasma membrane, termed lipid rafts. The mechanisms that underlie this interaction are starting to be unravelled. In this issue, Hayward ...

2005

Differential sorting and fate of endocytosed GPI-anchored proteins

Françoise Gisou van der Goot Grunberg, Laurence Gouzi Abrami

In this paper, we studied the fate of endocytosed glycosylphosphatidyl inositol anchored proteins (GPI- APs) in mammalian cells, using aerolysin, a bacterial toxin that binds to the GPI anchor, as a probe. We find that GPI-APs are transported down the endo ...

2002

Role for human immunodeficiency virus type 1 membrane cholesterol in viral internalization

Didier Trono, Laurence Gouzi Abrami, Priscilla Turelli

The membrane of human immunodeficiency virus type 1 (HIV-1) virions contains high levels of cholesterol and sphingomyelin, an enrichment that is explained by the preferential budding of the virus through raft microdomains of the plasma membrane. Upon deple ...

2002

Cross-talk between caveolae and glycosylphosphatidylinositol-rich domains

Françoise Gisou van der Goot Grunberg, Laurence Gouzi Abrami

Most mammalian cells have in their plasma membrane at least two types of lipid microdomains, non-invaginated lipid rafts and caveolae. Glycosylphosphatidylinositol (GPI)-anchored proteins constitute a class of proteins that are enriched in rafts but not ca ...

2001