Publications related to Efficient Kinetic Resolution of Sulfur-Stereogenic Sulfoximines by Exploiting (CpRhIII)-Rh-X-Catalyzed C-H Functionalization

Palladium-based supramolecular assemblies: from complex structures to water-soluble anion-receptors

The combination of palladium salts and bipyridyl ligands can lead to the formation of a large variety of coordination complexes, with different shapes and sizes, displaying a very versatile host-guest chemistry. Increasing their structural complexity remai ...

EPFL2024

Chalcogen bonding catalysis

Jieping Zhu

Catalysts play a major role in chemical synthesis, and catalysis is considered to be a green and economic process. Catalysis is dominated by covalent interactions between the catalyst and substrate. The design of non-covalent catalysts came into limelight ...

Royal Society of Chemistry2024

Chiral magnetohydrodynamics with zero total chirality

Kohei Kamada, Jennifer Waltraud Schober

We study the evolution of magnetic fields coupled with chiral fermion asymmetry in the framework of chiral magnetohydrodynamics with zero initial total chirality. The initial magnetic field has a turbulent spectrum peaking at a certain characteristic scale ...

American Physical Society2023

Artificial intelligence for natural product drug discovery

Philippe Schwaller, Florian Huber, Albert Hofstetter, Michael Alexander Skinnider

Developments in computational omics technologies have provided new means to access the hidden diversity of natural products, unearthing new potential for drug discovery. In parallel, artificial intelligence approaches such as machine learning have led to e ...

Nature Portfolio2023

Decay law of magnetic turbulence with helicity balanced by chiral fermions

Kohei Kamada, Jennifer Waltraud Schober

In plasmas composed of massless electrically charged fermions, chirality can be interchanged with magnetic helicity while preserving the total chirality through the quantum chiral anomaly. The decay of turbulent energy in plasmas such as those in the early ...

AMER PHYSICAL SOC2023

Enantio- and diastereoselective construction of vicinal C(sp(3)) centres via nickel-catalysed hydroalkylation of alkenes

Xile Hu, Chao Fan, Srikrishna Bera

In drug discovery, the proportion of aliphatic carbons (C(sp(3))) and the presence of chiral carbons in organic molecules are positively correlated to their chance of clinical success. Although methods exist for the synthesis of chiral C(sp(3))-rich molecu ...

2022

Outer automorphism anomalies

Brian Quinn Henning

We discuss anomalies associated with outer automorphisms in gauge theories based on classical groups, namely charge conjugations for SU(N) and parities for SO(2r). We emphasize the inequivalence (yet related by a flavor transformation) between two versions ...

Springer Nature2022

Low-scale leptogenesis with flavour and CP symmetries

Marco Drewes, Juraj Klaric, Yannis Georis

We consider a type-I seesaw framework endowed with a flavour symmetry, belonging to the series of non-abelian groups increment (3 n(2)) and increment (6 n(2)), and a CP symmetry. Breaking these symmetries in a non-trivial way results in the right-handed ne ...

Springer Nature2022

Ring-Opening Reactions of Aminocyclopropanes and Aminocyclobutanes

Mingming Wang

Nitrogen-containing compounds are an important class of molecules in medicinal chemistry, chemical biology, biochemistry, material sciences or environmental sciences. Organic nitrogen occurs in many forms, ranging from small building blocks such as urea, a ...

EPFL2022

Streamlined Alkylation via Nickel-Hydride-Catalyzed Hydrocarbonation of Alkenes

Xile Hu, Chao Fan, Srikrishna Bera, Zhikun Zhang

Compounds rich in sp(3)-hybridized carbons are desirable in drug discovery. Nickel-catalyzed hydrocarbonation of alkenes is a potentially efficient method to synthesize these compounds. By using abundant, readily available, and stable alkenes as pro-nucleo ...

2022