Peptide ligands for targeting and retention of nanoparticles and protein therapeutics in articular cartilage
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In the recent years medical diagnosis and surgery planning often require the precise evaluation of joint movements. This has led to exploit reconstructed three-dimensional models of the joint tissues obtained from CT or MR Images (for bones, cartilages, et ...
Peptides are an attractive class of molecules for the development of therapeutics because they combine unique properties such as high binding affinity, excellent target specificity, low toxicity and a relatively small mass. However, the short in vivo half- ...
Protease-sensitive macromolecular prodrugs have attracted interest for bio-responsive drug delivery to sites with up-regulated proteolytic activities such as inflammatory or cancerous lesions. Here we report the development of a novel polymeric photosensit ...
This paper presents results of experimental and numerical investigations on double-lap joints composed of pultruded GFRP profiles and polyurethane adhesive subjected to quasi-static axial tensile loading. The objective was to investigate the effect of the ...
This paper presents results of experimental and numerical investigations on double-lap joints composed of pultruded GFRP profiles and polyurethane adhesive subjected to quasi-static axial tensile loading. The objective was to investigate the effect of the ...
The extracellular matrix of dense, avascular tissues presents a barrier to entry for polymer-based therapeutics, such as drugs encapsulated within polymeric particles. Here, we present an approach by which polymer nanoparticles, suffciently small to enter ...
Ligands that specifically bind to articular cartilage tissues are disclosed, including uses for targeting therapeutics towards articular cartilage tissue and new materials for articular cartilage. The ligands are effective in vivo to target therapeutic mat ...
Articular cartilage plays important roles in weight-bearing, lubrication, and load distribution in articulating joints. The tissue is mostly extracellular matrix (>90% by volume) that is synthesized and remodeled by cells (chondrocytes) embedded within. Ad ...
Background. Intra-articular techniques (single and double bundles) are the most widely used procedures for the anterior cruciate lig- ament reconstruction. Lemaire introduced in 1967 the extra-articular techniques, and combined intra-articular and extra-ar ...
Injuries to the meniscus are often treated by partial or total meniscectomy, which is known to be associated with detrimental changes in joint function, ultimately increasing the risk of early degenerative joint diseases. Surgical approaches currently in u ...