Cells regulate iron homeostasis by posttranscriptional regulation of proteins responsible for iron uptake and storage. This requires RNA-binding activity of iron-regulatory proteins, IRP1 and IRP2. Two studies recently published in Science by Vashisht et al. (2009) and Salahudeen et al. (2009) reveal how cells adjust IRP2 activity.
Bruno Lemaitre, Jean Philippe Boquete, Igor Iatsenko, Alice Marra, Jasquelin Peña
Liviu Vanoaica, Maike Jaworski