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Design and validation of a telemetrically drived implantable glaucoma drainage device

Related publications (32)

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Purpose: To evaluate the efficacy of CO2 laser-assisted sclerectomy surgery (CLASS) compared with classic nonpenetrating deep sclerectomy (NPDS) with implant in medically uncontrolled glaucoma patients. Materials and Methods: Patients who underwent primary ...

Lippincott, Williams & Wilkins2016

Eyewatch, an Innovative Adjustable GDD for the Treatment of Glaucoma - in Vivo Results

Nikolaos Stergiopoulos, André Mermoud, Sylvain Roy, Adan Villamarin, Stéphane Bigler

PURPOSE: To report the in vivo results of a continuously adjustable glaucoma drainage device (GDD) in glaucoma surgery with rabbits. METHODS: Under general anesthesia, the AGDD was implanted on 12 white New-Zealand rabbits for duration of 6 months. The adj ...

Springer2016

JNK Inhibition Reduced Retinal Ganglion Cell Death after Ischemia/Reperfusion In Vivo and after Hypoxia In Vitro

Tatiana Favez

Mitogen-activated protein kinases (MAPKs) are key regulators that have been linked to cell survival and death. Among the main classes of MAPKs, c-jun N-terminal kinase (JNK) has been shown to mediate cell stress responses associated with apoptosis. In Vitr ...

Springer Int Publishing Ag2016

A New Noninvasively Adjustable Glaucoma Drainage Device

Adan Villamarin

Glaucoma is an irreversible disease affecting the eye, leading to progressive loss of vision and eventually to total blindness. It is often related to high intraocular pressure (IOP), which results from increased outflow resistance to aqueous humor. The fi ...

EPFL2014

In Vivo Testing of a Novel Adjustable Glaucoma Drainage Device

Nikolaos Stergiopoulos, André Mermoud, Sylvain Roy, Adan Villamarin, Stéphane Bigler

PURPOSE. We report on the in vivo testing of a novel noninvasively adjustable glaucoma drainage device (AGDD), which features an adjustable outflow resistance, and assess the safety and efficiency of this implant. METHODS. Under general anesthesia, the AGD ...

Association for Research in Vision and Ophthalmology2014

Notch signaling in the pigmented epithelium of the anterior eye segment promotes ciliary body development at the expense of iris formation

Freddy Radtke, Friedrich Beermann, Craig Nowell, Bhushan Sarode

The ciliary body and iris are pigmented epithelial structures in the anterior eye segment that function to maintain correct intra-ocular pressure and regulate exposure of the internal eye structures to light, respectively. The cellular and molecular factor ...

Wiley-Blackwell2014

A New Adjustable Glaucoma Drainage Device

Nikolaos Stergiopoulos, Sylvain Roy, Adan Villamarin, Stéphane Bigler

PURPOSE. This work is focused on the testing of a new experimental noninvasively adjustable glaucoma drainage device (AGDD) that allows for the control of its outflow resistance to modulate intraocular pressure (IOP) in a customized fashion. METHODS. Six A ...

Association for Research in Vision and Ophthalmology2014

Cellular signaling mediated by Notch receptors results in coordinated regulation of cell growth, survival and differentiation. In melanocytes, Notch signaling is essential for the maintenance of melanocytes and the melanocyte stem cell population. Whereas, ...

EPFL2013

Apparatus and methods for treating excess intraocular fluid

Nikolaos Stergiopoulos, Stéphane Bigler

An ocular drainage system is provided for treating diseases that produce elevated intraocular pressures, such as glaucoma, wherein the system includes an implantable device and an external control unit. The implantable device includes a non-invasively adju ...

2012

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Glaucoma results in an increase in the resistance of the aqueous humor outflow, which in turn leads to an increase of the intraocular pressure (IOP). Several treatments are proposed to reduce and stabilize the IOP that include medications, filtering surger ...

Elsevier Sci Ltd2012