Potentiation of apomorphine-induced climbing behaviour in mice by d-LSD

The climbing behaviour in mice was used for studying possible interaction(s) of d-LSD with dopamine receptors. 2. Doses of d-LSD ranging from 0.25 to 2.5 mg/kg injected intra-peritoneally constantly inhibited the climbing behaviour. 3. In contrast, when similar doses of d-LSD were injected 10 min before apomorphine (5 mg/kg), a constant potentiation of the apomorphine-induced climbing was observed. 4. Subsequent experiments performed with a neuroleptic (haloperidol) or a serotonin precursor (5-OH-tryptophan) compared to those of d-LSD with and without apomorphine would indicate that d-LSD alone displays typical serotoninergic syndrome (including inhibition of the climbing), whereas in the presence of apomorphine, an interaction at presynaptic receptors may possibly modulate dopaminergic activity.

Chat with Graph Search

Ask any question about EPFL courses, lectures, exercises, research, news, etc. or try the example questions below.

DISCLAIMER: The Graph Chatbot is not programmed to provide explicit or categorical answers to your questions. Rather, it transforms your questions into API requests that are distributed across the various IT services officially administered by EPFL. Its purpose is solely to collect and recommend relevant references to content that you can explore to help you answer your questions.

The climbing behaviour in mice was used for studying possible interaction(s) of d-LSD with dopamine receptors. 2. Doses of d-LSD ranging from 0.25 to 2.5 mg/kg injected intra-peritoneally constantly inhibited the climbing behaviour. 3. In contrast, when similar doses of d-LSD were injected 10 min before apomorphine (5 mg/kg), a constant potentiation of the apomorphine-induced climbing was observed. 4. Subsequent experiments performed with a neuroleptic (haloperidol) or a serotonin precursor (5-OH-tryptophan) compared to those of d-LSD with and without apomorphine would indicate that d-LSD alone displays typical serotoninergic syndrome (including inhibition of the climbing), whereas in the presence of apomorphine, an interaction at presynaptic receptors may possibly modulate dopaminergic activity.

Potentiation of apomorphine-induced climbing behaviour in mice by d-LSD

Graph Chatbot

Chat with Graph Search

Unveiling the complexity of learning and decision-making

A bistable inhibitory optoGPCR for multiplexed optogenetic control of neural circuits

GABAergic-like dopamine synapses in the brain

GABAergic-like dopamine synapses in the brain

Unveiling the complexity of learning and decision-making

A bistable inhibitory optoGPCR for multiplexed optogenetic control of neural circuits