Anguinomycins and Derivatives: Total Syntheses, Modeling, and Biological Evaluation of the Inhibition of Nucleocytoplasmic Transport
Graph Chatbot
Chat with Graph Search
Ask any question about EPFL courses, lectures, exercises, research, news, etc. or try the example questions below.
DISCLAIMER: The Graph Chatbot is not programmed to provide explicit or categorical answers to your questions. Rather, it transforms your questions into API requests that are distributed across the various IT services officially administered by EPFL. Its purpose is solely to collect and recommend relevant references to content that you can explore to help you answer your questions.
Tissue transglutaminase (tTG) has been implicated in the pathogenesis of Parkinson disease (PD). However, exactly how tTG modulates the structural and functional properties of alpha-synuclein (alpha-syn) and contributes to the pathogenesis of PD remains un ...
American Society for Biochemistry and Molecular Biology2009
Hexafluoro-2-butyne, CF(3)Cequivalent toCCF(3), reacts with the triangulo-clusters [Pt-3 (mu-CO)(3)(PR3)(3)] to give the diplatinum(o) compounds [Pt-2(CO)(2)(PR3)(2)(mu-eta(2):eta(2)-CF(3)Cequivalent toCCF(3))] {PR3=PPh3 (1), PBzPh(2) (2), PCy3 (3), (PPr3) ...
High-resolution transmission electron microscopy (HRTEM), electron microdiffraction, and X-ray diffraction were used to study hydroxyapatite specimens with particle sizes from a few nanometers to several hundreds of nanometers. Diffuse scattering (without ...
We present a 5 m long spectrometer for soft x rays to be used at a synchrotron radiation beamline for resonant x-ray emission spectroscopy and resonant inelastic x-ray scattering in the 400-1600 eV energy range. It is based on a variable line spacing spher ...
N,N-Bis(diphenylphosphino)ethylaniline compounds, Ph2PN-C6H4-C2H5, with ethyl groups at the ortho- and para-positions have been synthesized. Oxidation of the aminophosphines with hydrogen peroxide, elemental sulfur and selenium gave the corresponding ...
We report the total synthesis of a series of pyrrolizidine analogues of casuarine (1) and their 6-O-alpha-glucoside derivatives. The synthetic strategy is based on a totally regio- and stereoselective 1,3-dipolar cycloaddition of suitably substituted alken ...
A novel lithium salt, cyclobutane-1,1-dicarboxylic lithium was synthesized and characterized by NMR, IR, ESI-MS, X-ray single crystal analysis, and TG/DTG (TGA) thermal analysis. The crystal structure information reveals the coordination polymer nature and ...
Mol. dynamics simulations (MDS) of the structural rearrangements on the pathway leading to procaspase 3 (I) activation are presented. A retrostructural approach was used to build I from mature caspase 3 (II). The peptide bond that was cleaved during enzyme ...
Polarized fluorescence spectra were recorded in the vicinity of the Se and Br K edges on crystals of the selenated protein aldose reductase in complex with a brominated inhibitor molecule. The X-ray absorption, refraction and resonant scattering tensors as ...
2,2,6,6-Tetramethylpiperidine (tmpH) reacts smoothly with AlX3 (X = Cl, Br, I) and AlH2Cl.2THF to give the addn. compds. tmpH.AlX3 (X = Cl, Br, I) and tmpH.AlH2Cl, resp. These adducts of the secondary amine tmpH are stable and do not undergo intramol. elim ...