Publication

Emergent Connectivity Principles in the Neocortex

Related publications (48)

Reconstruction and visualization of large-scale volumetric models of neocortical circuits for physically-plausible in silico optical studies

Henry Markram, Felix Schürmann, Marwan Muhammad Ahmed Abdellah, Juan Bautista Hernando Vieites, Stefan Eilemann, Nicolas Antille

Background: We present a software workflow capable of building large scale, highly detailed and realistic volumetric models of neocortical circuits from the morphological skeletons of their digitally reconstructed neurons. The limitations of the existing a ...

2017

In Silico Brain Imaging Physically-plausible Methods for Visualizing Neocortical Microcircuitry

Marwan Muhammad Ahmed Abdellah

The recent years have witnessed growing interest in the power of scientific visualization for simulation-based neuroscience. The research presented in this thesis develops methods to generate physically-realistic visualizations of neocortical models recons ...

EPFL2017

Generative models of the human connectome

Jean-Philippe Thiran, Alessandra Griffa, Patric Hagmann, Olaf Sporns

The human connectome represents a network map of the brain's wiring diagram and the pattern into which its connections are organized is thought to play an important role in cognitive function. The generative rules that shape the topology of the human conne ...

Academic Press Inc Elsevier Science2016

Imaging the Dynamics of Neocortical Population Activity in Behaving and Freely Moving Mammals

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The development of functional imaging techniques applicable to neuroscience and covering a wide range of spatial and temporal scales has greatly facilitated the exploration of the relationships between cognition, behaviour and electrical brain activity. Fo ...

Springer-Verlag Berlin2015

Motor Control in the Mouse Whisker System

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The motor systems of the mammalian brain are a remarkable product of many millions of years of evolution. It is the motor systems that make us and other mammals mobile, that guide our actions in response to sensory information and conversely modulate the v ...

EPFL2015

The topology of structural brain connectivity in diseases and spatio-temporal connectomics

Alessandra Griffa

The brain is a complex system, composed of multiple neural units interconnected at different spatial and temporal scales. Diffusion MRI allows probing in vivo the anatomical connectivity between different cortical areas through white matter tracts. In para ...

EPFL2015

Connectivity Analysis of Brain States and Applications in Brain-Computer Interfaces

Huaijian Zhang

Human brain is organized by a large number of functionally correlated but spatially distributed cortical neurons. Cognitive processes are usually associated with dynamic interactions among multiple brain regions. Therefore, the understanding of brain funct ...

EPFL2015

High Bandwidth Synaptic Communication and Frequency Tracking in Human Neocortex

Michele Giugliano

Neuronal firing, synaptic transmission, and its plasticity form the building blocks for processing and storage of information in the brain. It is unknown whether adult human synapses are more efficient in transferring information between neurons than roden ...

Public Library Science2014

Synaptic Computation and Sensory Processing in Neocortical Layer 2/3

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Computations in neocortical circuits are predominantly driven by synaptic integration of excitatory glutamatergic and inhibitory GABAergic inputs. New optical, electrophysiological, and genetic methods allow detailed in vivo investigation of the superficia ...

Cell Press2013

Network Activity and Plasticity

Vincent Delattre

The cortex must maintain balanced levels of neural activity to correctly integrate inputs and to provide contextually meaningful outputs. Neuronal excitation is counterbalanced by various forms of inhibition such as spike frequency adaptation, short- and l ...

EPFL2013

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