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The specificity of TRIM5{alpha}-mediated restriction is influenced by its coiled-coil domain
Related publications (33)
PSGL-1 is an evolutionarily conserved antiviral restriction factor
The arms race between viruses and their hosts shaped the evolutionary history and the genome composition of both parties. Restriction factors are the first-line antiviral effectors encoded by the host genomes and are often conserved through evolution to pr ...
AMER SOC MICROBIOLOGY2023Frequency selection in a gravitationally stretched capillary jet in the jetting regime
François Gallaire, Isha Shukla
A capillary jet falling under the effect of gravity continuously stretches while thinning downstream. We report here the effect of external periodic forcing on such a spatially varying jet in the jetting regime. Surprisingly, the optimal forcing frequency ...
CAMBRIDGE UNIV PRESS2020The population genetics of crypsis in vertebrates: recent insights from mice, hares, and lizards
Jeffrey David Jensen, Susanne Petra Pfeifer, Stefan Jean Laurent
By combining well-established population genetic theory with high-throughput sequencing data from natural populations, major strides have recently been made in understanding how, why, and when vertebrate populations evolve crypsis. Here, we focus on backgr ...
NATURE PUBLISHING GROUP2020A cell fitness selection model for neuronal survival during development
Developmental cell death plays an important role in the construction of functional neural circuits. In vertebrates, the canonical view proposes a selection of the surviving neurons through stochastic competition for target-derived neurotrophic signals, imp ...
2019Dissecting HIV Virulence: Heritability of Setpoint Viral Load, CD4+ T Cell Decline and Per-Parasite Pathogenicity
Jacques Fellay, Gabriel Leventhal
Pathogen strains may differ in virulence because they attain different loads in their hosts, or because they induce different disease-causing mechanisms independent of their load. In evolutionary ecology, the latter is referred to as" per-parasite pathogen ...
Oxford University Press2018Signatures of selection and environmental adaptation across the goat genome post-domestication
Stéphane Joost, Estelle Rochat
Background: Since goat was domesticated 10,000 years ago, many factors have contributed to the differentiation of goat breeds and these are classified mainly into two types: (i) adaptation to different breeding systems and/or purposes and (ii) adaptation t ...
BMC2018Inferring the age and strength of mutations evolving under positive selection
A fundamental goal of population genetics is to determine and quantify the interplay of mutation, natural selection, genetic drift and migration in shaping allelic frequency changes that underpin evolution-ary change. In this dissertation, I present comput ...
EPFL2017NCoR1 restrains thymic negative selection by repressing Bim expression to spare thymocytes undergoing positive selection
Johan Auwerx, Shuo Zhang, Na Zhang, Hui Xiao, Ye Zheng
Thymocytes must pass both positive and negative selections to become mature T cells. Negative selection purges thymocytes whose T-cell receptors (TCR) exhibit high affinity to self-peptide MHC complexes (self pMHC) to avoid autoimmune diseases, while posit ...
Nature Publishing Group2017A unified measure of linear and nonlinear selection on quantitative traits
Lande and Arnold's approach to quantifying natural selection has become a standard tool in evolutionary biology due to its simplicity and generality. It treats linear and nonlinear selection in two separate frameworks, generating coefficients of selection ...
Wiley2017Genetic diversity of two Daphnia-infecting microsporidian parasites, based on sequence variation in the internal transcribed spacer region
Background: Microsporidia are spore-forming obligate intracellular parasites that include both emerging pathogens and economically important disease agents. However, little is known about the genetic diversity of microsporidia. Here, we investigated patter ...
Biomed Central Ltd2016