Publication
Myofibroblasts work best under stress
Related publications (38)
Dissecting the roles of endothelin, TGF-beta and GM-CSF on myofibroblast differentiation by keratinocytes
Jean-Jacques Meister, Boris Hinz
Myofibroblasts are specialized fibroblasts that contribute to wound healing by producing extracellular matrix and by contracting the granulation tissue. They appear in a phase of wound healing when the dermis strongly interacts with activated epidermal ker ...
Schattauer2004Cell-matrix and cell-cell contacts of myofibroblasts: role in connective tissue remodeling
It is presently accepted that fibroblast/myofibroblast modulation represents a crucial step in granulation tissue contraction and in the production of the connective tissue deformations typical of fibrocontractive diseases. In addition to synthesizing extr ...
Schattauer2003Mechanisms of force generation and transmission by myofibroblasts
The myofibroblast has been shown to have a key role in tissue reconstruction after injury and pathological changes characterized by fibrosis. Force generation by the myofibroblast depends on the isometric contraction of stress fibers containing alpha-smoot ...
Elsevier2003Repair of bone defects using synthetic mimetics of collagenous extracellular matrices
Matthias Lütolf, Jeffrey Alan Hubbell, Randoald Müller
We have engineered synthetic poly(ethylene glycol) (PEG)-based hydrogels as cell-ingrowth matrices for in situ bone regeneration. These networks contain a combination of pendant oligopeptide ligands for cell adhesion (RGDSP) and substrates for matrix metal ...
2003Alpha-smooth muscle actin is crucial for focal adhesion maturation in myofibroblasts
Cultured myofibroblasts are characterized by stress fibers, containing alpha-smooth muscle actin (alpha-SMA) and by supermature focal adhesions (FAs), which are larger than FAs of alpha-SMA-negative fibroblasts. We have investigated the role of alpha-SMA f ...
American Society for Cell Biology2003Cell ingrowth matrixes in presentation and release of bioactive signals in tissue morphogenesis
Matthias Lütolf, Jeffrey Alan Hubbell
Biomimetic polymer gels have been developed to display the key features of the extracellular matrix, namely presentation of adhesion sites, presentation of growth factor binding sites and release, and ability to be remodeled by cell-assocd. proteases. [on ...
2001Dynamics of adhesive rupture between fibroblasts and fibronectin: microplate manipulations and deterministic model
To characterize the dynamics of cell-substrate adhesive rupture, we used a novel micromanipulation technique, in which individual fibroblasts seized on a rigid microplate were placed into contact with a fibronectin-coated flexible microplate, then pulled a ...
Springer Verlag2000Murine macrophage behavior on peptide-grafted polyethyleneglycol-containing networks
Polyethyleneglycol-based networks were employed as substrates to graft bioactive peptides to study macrophage interactions with materials. Our overall objective was to utilize biologically active factors to stimulate certain macrophage function on material ...
1998