Publication
The cell cycle of parasitic protozoa: potential for chemotherapeutic exploitation
Related publications (51)
Identification of New Vulnerabilities in Conjunctival Melanoma Using Image-Based High Content Drug Screening
Gerardo Turcatti, Fabien Kuttler, Mathieu Quinodoz, Olivier Michielin
Recent evidence suggests that numerous similarities exist between the genomic landscapes of both conjunctival and cutaneous melanoma. Since alterations of several components of the MAP kinases, PI3K/mTOR, and cell cycle pathways have been reported in conju ...
2022Can Precision Electrophile Signaling Make a Meaningful and Lasting Impression in Drug Design?
For several years, drugs with reactive electrophilic appendages have been developed. These units typically confer prolonged residence time of the drugs on their protein targets, and may assist targeting shallow binding sites and/or improving the drug-prote ...
WILEY-V C H VERLAG GMBH2021Long noncoding RNA SNHG12 integrates a DNA-PK-mediated DNA damage response and vascular senescence
Johan Auwerx, Norman Lionel Moullan, Lei Chen
Long noncoding RNAs (lncRNAs) are emerging regulators of biological processes in the vessel wall; however, their role in atherosclerosis remains poorly defined. We used RNA sequencing to profile lncRNAs derived specifically from the aortic intima of Ldlr(- ...
AMER ASSOC ADVANCEMENT SCIENCE2020Identification of novel PCTAIRE-1/CDK16 substrates using a chemical genetic screen
Kei Sakamoto, Maria Deak, Caterina Collodet
PCTAIRE-1 (also known as cyclin-dependent protein kinase (CDK) 16), is a Ser/Thr kinase that has been implicated in many cellular processes, including cell cycle, spermatogenesis, neurite outgrowth, and vesicle trafficking. Most recently, it has been propo ...
2019Physiological regulation of the CDK16/PCTAIRE-1 protein kinase and its proposed role in the brain
Saifeldin Nasser Mohamed Ibrahim Shehata
Cell signalling, mediated to a large extent by protein kinase phosphorylation, plays a vital role in regulation of cellular function. PCTAIRE-1 (also known as cyclin-dependent protein kinase (CDK)16), is a Ser/Thr kinase that has been implicated in many ce ...
EPFL2017CDK4 Phosphorylates AMPK alpha 2 to Inhibit Its Activity and Repress Fatty Acid Oxidation
Anita Nasrallah, Caterina Collodet, Judit Castillo Armengol
The roles of CDK4 in the cell cycle have been extensively studied, but less is known about the mechanisms underlying the metabolic regulation by CDK4. Here, we report that CDK4 promotes anaerobic glycolysis and represses fatty acid oxidation in mouse embry ...
Cell Press2017Identification of genetic interactors of ypa2 in Schizosaccharomyces pombe
In this study, the fission yeast Schizosaccharomyces pombe was used as a model system to study the cellular signaling that underlies cell cycle progression. Phosphorylation plays an important part in the regulation of this process. Kinases catalyze the tra ...
EPFL2016Identification and functional characterization of protein kinases that modulate Notch signaling under physiological conditions and in cancer
The Notch signaling pathway is a key regulator of cell fate decisions in embryonic development and in adult tissue homeostasis. Mounting evidence suggests that Notch signaling is frequently deregulated in human neoplasms, where depending upon the cellular ...
EPFL2016Unexpected Off-Targets and Paradoxical Pathway Activation by Kinase Inhibitors
Protein kinase inhibitors are an increasingly important class of targeted anticancer therapeutics. More than two dozen new drugs of this class have entered routine clinical use over the past decade. This review article focuses on how the development of met ...
2015Cyclin Y phosphorylation- and 14-3-3-binding-dependent activation of PCTAIRE-1/CDK16
PCTAIRE-1 [also known as cyclin-dependent kinase 16 (CDK16)] is implicated in various physiological processes such as neurite outgrowth and vesicle trafficking; however, its molecular regulation and downstream targets are largely unknown. Cyclin Y has rece ...
Portland Press Ltd2015