Publications related to Reversible acetylation of PGC-1: connecting energy sensors and effectors to guarantee metabolic flexibility

NAD(+)-Dependent Activation of Sirt1 Corrects the Phenotype in a Mouse Model of Mitochondrial Disease

Johan Auwerx, Eija Riitta Pirinen, Wei Li

Mitochondrial disorders are highly heterogeneous conditions characterized by defects of the mitochondrial respiratory chain. Pharmacological activation of mitochondrial biogenesis has been proposed as an effective means to correct the biochemical defects a ...

Elsevier2014

Stable blow up dynamics for energy supercritical wave equations

Roland Donninger

We study the semilinear wave equation

\displaystyle \partial _t^2 \psi -\Delta \psi =\vert\psi \vert^{p-1}\psi

for

p > 3

with radial data in three spatial dimensions. There exists an explicit solution which blows up at

t=T>0

given by $\displaystyl ...

American Mathematical Society2014

Simulation of Urban Energy Flow: A Graph Theory Inspired Approach

Jean-Louis Scartezzini, Jérôme Henri Kämpf, Diane Perez

Following the increased consciousness regarding global warming and other environmental issues, there is a growing urge in cities for a more rational energy supply and use in buildings. In parallel, the range of possible actions has broaden, from building r ...

EPFL Solar Energy and Building Physics Laboratory (LESO-PB)2013

ECOS: Integrated and practical energy planning for new districts

François Maréchal, Jakob Moritz Fabian Rager, Cédric Dorsaz

In this paper, we propose a unified method for the integrated energy planning during the development of new districts for all involved actors. Taking energy related problems such as equipment choice and size, costs and environmental impact early into consi ...

2013

MEU: An urban energy management tool for communities and multi-energy utilities

François Maréchal, Gaëtan Cherix, Massimiliano Capezzali, Jakob Moritz Fabian Rager, Damien Rebeix

In order to facilitate urban energy management and energy planning, the project MEU developed a web based tool as a decision support system for decision makers. Using a web based approach minimizes the effort on the client site as no software needs to be i ...

2013

A codimension two stable manifold of near soliton equivariant wave maps

Joachim Krieger, Daniel Tataru

We consider finite-energy equivariant solutions for the wave map problem from ℝ2+1 to S2 which are close to the soliton family. We prove asymptotic orbital stability for a codimension-two class of initial data which is small with respect to a stronger topo ...

Mathematical Science Publ2013

MicroRNA-22 (miR-22) Overexpression Is Neuroprotective via General Anti-Apoptotic Effects and May also Target Specific Huntington's Disease-Related Mechanisms

Ana Jovicic

Background: Whereas many causes and mechanisms of neurodegenerative diseases have been identified, very few therapeutic strategies have emerged in parallel. One possible explanation is that successful treatment strategy may require simultaneous targeting o ...

Public Library Science2013

Analysis Of An Energy-Based Atomistic/Continuum Approximation Of A Vacancy In The 2D Triangular Lattice

We present an a priori error analysis of a practical energy based atomistic/continuum coupling method (A. V. Shapeev, Multiscale Model. Simul., 9(3): 905-932, 2011) in two dimensions, for finite-range pair-potential interactions, in the presence of vacancy ...

Amer Mathematical Soc2013

Metabolic Characterization of a Sirt5 deficient mouse model

Johan Auwerx, Kristina Schoonjans, Norman Lionel Moullan, Lilia Noriega Lopez, Jiujiu Yu

Sirt5, localized in the mitochondria, is a member of sirtuin family of NAD(+)-dependent deacetylases. Sirt5 was shown to deacetylate and activate carbamoyl phosphate synthase 1. Most recently, Sirt5 was reported to be the predominant protein desuccinylase ...

Nature Publishing Group2013

Enthalpy and exergy analysis in the framework of a district scale energy balance

Cédric Lambiel

This report presents a study of an enthalpy and exergy analysis in the framework of a district scale energy balance. Energy demand (heating, cooling and lighting) for buildings represents more than 30 % of the total worlds energy use. Main eﬀorts have been ...

2012

Reversible acetylation of PGC-1: connecting energy sensors and effectors to guarantee metabolic flexibility

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NAD(+)-Dependent Activation of Sirt1 Corrects the Phenotype in a Mouse Model of Mitochondrial Disease

Stable blow up dynamics for energy supercritical wave equations

Simulation of Urban Energy Flow: A Graph Theory Inspired Approach

ECOS: Integrated and practical energy planning for new districts

MEU: An urban energy management tool for communities and multi-energy utilities

A codimension two stable manifold of near soliton equivariant wave maps

MicroRNA-22 (miR-22) Overexpression Is Neuroprotective via General Anti-Apoptotic Effects and May also Target Specific Huntington's Disease-Related Mechanisms

Analysis Of An Energy-Based Atomistic/Continuum Approximation Of A Vacancy In The 2D Triangular Lattice

Metabolic Characterization of a Sirt5 deficient mouse model

Enthalpy and exergy analysis in the framework of a district scale energy balance

ECOS: Integrated and practical energy planning for new districts

Stable blow up dynamics for energy supercritical wave equations

MicroRNA-22 (miR-22) Overexpression Is Neuroprotective via General Anti-Apoptotic Effects and May also Target Specific Huntington's Disease-Related Mechanisms

Enthalpy and exergy analysis in the framework of a district scale energy balance

Analysis Of An Energy-Based Atomistic/Continuum Approximation Of A Vacancy In The 2D Triangular Lattice

MEU: An urban energy management tool for communities and multi-energy utilities

NAD(+)-Dependent Activation of Sirt1 Corrects the Phenotype in a Mouse Model of Mitochondrial Disease

A codimension two stable manifold of near soliton equivariant wave maps

Simulation of Urban Energy Flow: A Graph Theory Inspired Approach

Metabolic Characterization of a Sirt5 deficient mouse model