Macromolecular crowdingThe phenomenon of macromolecular crowding alters the properties of molecules in a solution when high concentrations of macromolecules such as proteins are present. Such conditions occur routinely in living cells; for instance, the cytosol of Escherichia coli contains about 300–400mg/ml of macromolecules. Crowding occurs since these high concentrations of macromolecules reduce the volume of solvent available for other molecules in the solution, which has the result of increasing their effective concentrations.
CytosolThe cytosol, also known as cytoplasmic matrix or groundplasm, is one of the liquids found inside cells (intracellular fluid (ICF)). It is separated into compartments by membranes. For example, the mitochondrial matrix separates the mitochondrion into many compartments. In the eukaryotic cell, the cytosol is surrounded by the cell membrane and is part of the cytoplasm, which also comprises the mitochondria, plastids, and other organelles (but not their internal fluids and structures); the cell nucleus is separate.
Monte Carlo methodMonte Carlo methods, or Monte Carlo experiments, are a broad class of computational algorithms that rely on repeated random sampling to obtain numerical results. The underlying concept is to use randomness to solve problems that might be deterministic in principle. They are often used in physical and mathematical problems and are most useful when it is difficult or impossible to use other approaches. Monte Carlo methods are mainly used in three problem classes: optimization, numerical integration, and generating draws from a probability distribution.
AxeAn axe (æks sometimes ax in American English; see spelling differences) is an implement that has been used for millennia to shape, split, and cut wood, to harvest timber, as a weapon, and as a ceremonial or heraldic symbol. The axe has many forms and specialised uses but generally consists of an axe head with a handle, also called a haft or a helve. Before the modern axe, the stone-age hand axe without a handle was used from 1.5 million years BP. Hafted axes (those with a handle) date only from 6,000 BC.
Markov chain Monte CarloIn statistics, Markov chain Monte Carlo (MCMC) methods comprise a class of algorithms for sampling from a probability distribution. By constructing a Markov chain that has the desired distribution as its equilibrium distribution, one can obtain a sample of the desired distribution by recording states from the chain. The more steps that are included, the more closely the distribution of the sample matches the actual desired distribution. Various algorithms exist for constructing chains, including the Metropolis–Hastings algorithm.
Battle axeA battle axe (also battle-axe, battle ax, or battle-ax) is an axe specifically designed for combat. Battle axes were specialized versions of utility axes. Many were suitable for use in one hand, while others were larger and were deployed two-handed. Axes designed for warfare ranged in weight from just over , and in length from just over to upwards of , as in the case of the Danish axe or the sparth axe. Cleaving weapons longer than 150 cm would arguably fall into the category of polearms.
Hand axeA hand axe (or handaxe or Acheulean hand axe) is a prehistoric stone tool with two faces that is the longest-used tool in human history. It is made from stone, usually flint or chert that has been "reduced" and shaped from a larger piece by knapping, or hitting against another stone. They are characteristic of the lower Acheulean and middle Palaeolithic (Mousterian) periods, roughly 1.6 million years ago to about 100,000 years ago, and used by Homo erectus and other early humans, but rarely by Homo sapiens.
Carbon nanotubeA carbon nanotube (CNT) is a tube made of carbon with a diameter in the nanometer range (nanoscale). They are one of the allotropes of carbon. Single-walled carbon nanotubes (SWCNTs) have diameters around 0.5–2.0 nanometers, about 100,000 times smaller than the width of a human hair. They can be idealized as cutouts from a two-dimensional graphene sheet rolled up to form a hollow cylinder. Multi-walled carbon nanotubes (MWCNTs) consist of nested single-wall carbon nanotubes in a nested, tube-in-tube structure.
GrapheneGraphene (ˈgræfiːn) is an allotrope of carbon consisting of a single layer of atoms arranged in a hexagonal lattice nanostructure. The name is derived from "graphite" and the suffix -ene, reflecting the fact that the graphite allotrope of carbon contains numerous double bonds. Each atom in a graphene sheet is connected to its three nearest neighbors by σ-bonds and a delocalised π-bond, which contributes to a valence band that extends over the whole sheet.
