A new synthetic access to furo[3,2-f]chromene analogues of an antimycobacterial
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We introduce a simplified protein model where the water degrees of freedom appear explicitly (although in an extremely simplified fashion). Using this model we are able to recover both the warm and the cold protein denaturation within a single framework, w ...
An asymmetric synthesis of the 3,5-dihydroxycyclohexanone subunit of baconipyrones A and B, as well as that of the hydroxydiketone subunit of baconipyrones C and D ((-)-(4S,6S)-4,6-dimethyl-5-hydroxynonan-3,7-dione), is described. Key steps include sulfur ...
A novel concept for triggering conformational transitions, and thus changes in structure and function, in peptides with a switching element S provides intriguing perspectives for studying mol. processes that play a key role, for example, in early events of ...
We study the problem of finding a characterization for the channel that results when a queue is operated under multiple access conditions. In such systems, the mechanism by which different sources gain access to the channel plays a fundamental role in defi ...
The central region of the matrix protein p17 of HIV-1 is known to be essential during virus assembly. We substituted alanines for amino acid triplets in this region of p17 (amino acid residues 47 to 55: NPG LLE TSE). Introduction of the respective mutation ...
Proteins have a complex free-energy landscape because of their rich topol. and the nature of their nonbonded interaction potential. This has important consequences because the roughness of the landscape affects the ease with which a chain folds and also de ...
This paper presents results of our research that targets the improvement of workgroup efficiency with technological support for the management of group-related information. We built a software tool that enables all the people in a workgroup to work with in ...
This paper presents results of our research that targets the improvement of workgroup efficiency with technological support for the management of group-related information. We built a software tool that enables all the people in a workgroup to work with in ...