Publication
Towards an immunodiagnostic test for leprosy
Related publications (62)
To B or not to B: B cells and the Th2-type immune response to helminths
Similar T helper (Th)2-type immune responses are generated against different helminth parasites, but the mechanisms that initiate Th2 immunity, and the specific immune components that mediate protection against these parasites, can vary greatly. B cells ar ...
2011Host genetic determinants of T cell responses to the MRKAd5 HIV-1 gag/pol/nef vaccine in the step trial
Understanding how human genetic variation impacts individual response to immunogens is fundamental for rational vaccine development. To explore host mechanisms involved in cellular immune responses to the MRKAd5 human immunodeficiency virus type 1 (HIV-1) ...
2011PPS nanoparticles as versatile delivery system to induce systemic and broad mucosal immunity after intranasal administration
Eleonora Simeoni, Jeffrey Alan Hubbell, Melody Swartz, Mikaël Martino, Armando Stano
Degradable polymer nanoparticles (NPs, 50nm) based on polypropylene sulfide (PPS) were conjugated to thiolated antigen and adjuvant proteins by reversible disulfide bonds and evaluated in mucosal vaccination. Ovalbumin was used as a model antigen, and anti ...
Elsevier2011Engineering Erythrocyte Affinity for Improved Pharmacokinetics and Immune Tolerogenesis
The clinical success of recombinant protein therapeutics in the treatment of disease is a hallmark of modern medical research, yet there remain numerous unaddressed issues regarding their delivery and immunogenicity. Regardless of in vivo efficacy, the bio ...
EPFL2011Comparative genomics of Esx genes from clinical isolates of Mycobacterium tuberculosis provides evidence for gene conversion and epitope variation
Stewart Cole, Jacques Rougemont, Swapna Uplekar
The 23-membered Esx protein family is involved in the host-pathogen interactions of Mycobacterium tuberculosis. These secreted proteins are among the most immunodominant antigens recognized by the human immune system and have thus been used to develop vacc ...
2011Spontaneous phthiocerol dimycocerosate-deficient variants of Mycobacterium tuberculosis are susceptible to gamma interferon-mediated immunity
John McKinney, Swapna Uplekar, Anna De Graff Tischler
Onset of the adaptive immune response in mice infected with Mycobacterium tuberculosis is accompanied by slowing of bacterial replication and establishment of a chronic infection. Stabilization of bacterial numbers during the chronic phase of infection is ...
2011Evidence for a TCR Affinity Threshold Delimiting Maximal CD8 T Cell Function
Pedro Romero, Olivier Michielin, Nathalie Rufer
Protective adaptive immune responses rely on TCR-mediated recognition of Ag-derived peptides presented by self-MHC molecules. However, self-Ag (tumor)-specific TCRs are often of too low affinity to achieve best functionality. To precisely assess the relati ...
2010Antigen delivery to dendritic cells by poly(propylene sulfide) nanoparticles with disulfide conjugated peptides: Cross-presentation and T cell activation
Jeffrey Alan Hubbell, Melody Swartz, Sachiko Hirosue, Iraklis Kourtis
Vaccines aiming to activate cytotoxic T cells require cross-presentation of exogenous antigen by antigen-presenting cells (APCs). We recently developed a synthetic nanoparticle vaccine platform that targets lymph node-resident dendritic cells (DCs), capabl ...
Elsevier2010Towards anti-virulence drugs targeting ESX-1 mediated pathogenesis of Mycobacterium tuberculosis
Stewart Cole, Florence Pojer, Jeffrey Chen, Benjamin Blasco
Mycobacterium tuberculosis (M. tb) the causative agent of tuberculosis (TB) causes 1.7 million deaths annually. According to the World Health Organization, in some areas of the world, 25% of TB cases are due to multi- or extensively drug resistant M. tb st ...
Elsevier2010Are variable-number tandem repeats appropriate for genotyping Mycobacterium leprae?
Comparative genomics analysis of the Tamil Nadu strain of Mycobacterium leprae has uncovered several polymorphic sites with potential as epidemiological tools. In this study we compared the stability of two different markers of genomic biodiversity of M. l ...
2008